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Adenosine stress myocardial perfusion detected with CT compared with attenuation-corrected SPECT
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Cardiology in Linköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Radiology. Östergötlands Läns Landsting.
Östergötlands Läns Landsting.
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2011 (English)In: EUROPEAN HEART JOURNAL SUPPLEMENTS, Oxford University Press , 2011, Vol. 13, no A, A31-A31 p.Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Purpose: To asses adenosine stress myocardial perfusion by cardiac CT and compare with simultaneously performed attenuation corrected SPECT.

Methods: 11 patients, 9 men and 2 women >2months post primary PCI, with manifest myocardial damage and remaining stenoses in the coronary circulation, were studied with myocardial perfusion CT under vasodilatory stress. The investigation started with a topogram followed by a testbolus of iodine whereafter the coronary artery study was performed in sequence mode. Adenosine was then infused for at least five minutes at the standard rate of 140ug/kg/min. After three minutes, 6 MBq/kg of 99mTc-tetrofosmin was injected immediately followed by 80ml iodine contrast. The wash-in of iodine was monitored by CT scanning of a 7cm long cardiac volume segment every other second for 22s. One hour after the CT scan, myocardial SPECT was performed. Scanning required the patients to tolerate breath holding for 22s, have a heart rate <80/min and body weight <85kg, and their kidney function should allow 140ml 370mg iodine contrast to be given.

Results: All 11 patients tolerated the full adenosine infusion and scanning was successful. One patient could not be analyzed due to noisy images. In two patients, the limited scanning volume did not cover the entire base of the heart. Three patients had no defect on SPECT. Patients with a defect had on average myocardial blood flow 80ml/100ml tissue/min in the defect area and 142ml in the segments with the highest perfusion, while patients without defect had 98 and 141ml, respectively.

Conclusion: Peak myocardial perfusion may be determined with CT under adenosine stress and compared with attenuation corrected SPECT. Initial experience shows that the method is sensitive to timing of bolus, to noisy images and results may diverge from those obtained with SPECT.

Place, publisher, year, edition, pages
Oxford University Press , 2011. Vol. 13, no A, A31-A31 p.
Series
EUROPEAN HEART JOURNAL SUPPLEMENTS, ISSN 1520-765X ; A
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-69922ISI: 000291748800089OAI: oai:DiVA.org:liu-69922DiVA: diva2:433190
Conference
10th International Conference of Non-Invasive Cardiovascular Imaging
Available from: 2011-08-09 Created: 2011-08-08 Last updated: 2014-05-08

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Engvall, JanGjerde, Marcusde Geer, JakobQuick, Petter

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Clinical PhysiologyFaculty of Health SciencesDepartment of Clinical Physiology in LinköpingCardiologyDepartment of Cardiology in LinköpingRadiologyÖstergötlands Läns LandstingCenter for Medical Image Science and Visualization (CMIV)Department of Radiology in Linköping
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