liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Impaired compensatory response to hypovolaemic circulatory stress in type 1 diabetes mellitus
Linköping University, Department of Medical and Health Sciences, Physiology. Linköping University, Faculty of Health Sciences.
Helsingborg Hospital.
Linköping University, Department of Medical and Health Sciences, Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Thoracic and Vascular Surgery in Östergötland.ORCID iD: 0000-0002-9095-403X
2011 (English)In: DIABETES and VASCULAR DISEASE RESEARCH, ISSN 1479-1641, Vol. 8, no 2, 136-142 p.Article in journal (Refereed) Published
Abstract [en]

Diabetes mellitus is associated with decreased haemodynamic stability and reduced tolerance to hypovolaemia. Compensatory haemodynamic responses during experimental hypovolaemia in type I diabetes patients with (DMR+) and without (DMR-) retinopathy as well as healthy controls (C) were studied. Lower body negative pressure created hypovolaemic circulatory stress. Volumetric techniques were used to assess the compensatory capacitance response (redistribution of peripheral venous blood to the central circulation) and to assess capillary fluid absorption from tissue to blood. The compensatory capacitance response was 1/3 lower in DMR+ compared with C (p = 0.002) and DMR- (p = 0.01). Net capillary fluid absorption was reduced by one-third in DMR- and DMR+ compared with C (each p less than 0.05). Type I diabetes patients with retinopathy demonstrate reduced mobilisation of peripheral venous blood to the central circulation. Furthermore, type I diabetes patients present with impaired capillary fluid absorption, which in combination with potentially decreased sympathetic vasoconstriction impedes cardiovascular homeostasis during acute hypovolaemic stress.

Place, publisher, year, edition, pages
Sherborne Gibbs Ltd , 2011. Vol. 8, no 2, 136-142 p.
Keyword [en]
Capacitance response; cardiovascular autonomic neuropathy; diabetes; retinopathy; surgery; venous compliance
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-69921DOI: 10.1177/1479164111404576ISI: 000292119600005OAI: oai:DiVA.org:liu-69921DiVA: diva2:433192
Available from: 2011-08-09 Created: 2011-08-08 Last updated: 2017-03-27

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Lindenberger, MarcusLänne, Toste

Search in DiVA

By author/editor
Lindenberger, MarcusLänne, Toste
By organisation
PhysiologyFaculty of Health SciencesDepartment of Thoracic and Vascular Surgery in Östergötland
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 79 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf