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Depressive symptoms and inflammation in patients hospitalized for heart failure
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Cardiology UHL. Linköping University, Department of Social and Welfare Studies, Health, Activity, Care.ORCID iD: 0000-0001-7431-2873
University of Groningen.
Swedish Defence Research Agency.
University of Groningen.
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2011 (English)In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 161, no 6, 1053-1059 p.Article in journal (Refereed) Published
Abstract [en]

Background Depressive symptoms in patients with heart failure (HF) are common and might be associated with inflammation. No studies have examined both the cross-sectional and prospective association between inflammation and depressive symptoms in patients with HF with adequate correction for disease severity. The aim of this study was to describe if the cytokines interleukin-6 (IL-6) and C-reactive protein (CRP) are associated with depressive symptoms in hospitalized HF patients. Methods Data from 517 patients hospitalized for HF from the COACH study were analyzed on inflammation markers (IL-6 and CRP) and depressive symptoms (Center for Epidemiological Studies Depression-Scale). Results Heart failure patients with depressive symptoms (n = 208, 40%) had significantly higher plasma values of IL-6 (median 12.8 pg/mL vs median 11.0 pg/mL, P = .018) and CRP (median 2.4 mg/mL vs median 2.1 mg/mL, P = .03) compared with the nondepressed patients. Structural equation modelling showed that the factor inflammation (including IL-6 and CRP) was associated with depressive symptoms (beta = 0.18, P less than .05) when left ventricular ejection fraction and plasma values brain natriuretic peptides were included in the model. A small negative (beta = -0.18, P less than .05) effect was found between inflammation at baseline and the change in depressive symptoms during the 18 months of follow-up. Conclusions Higher levels of inflammatory markers are independently associated with depressive symptoms in HF patients, even after correcting for disease severity. There is no clear relationship between inflammation at baseline and depressive symptoms during the 18 months of follow-up.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam , 2011. Vol. 161, no 6, 1053-1059 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-69902DOI: 10.1016/j.ahj.2011.03.011ISI: 000291343000007OAI: diva2:433285
Available from: 2011-08-09 Created: 2011-08-08 Last updated: 2013-09-18

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Johansson, PeterJaarsma, Tiny
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