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Zebrafish Models to Study Hypoxia-Induced Pathological Angiogenesis in Malignant and Nonmalignant Diseases
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences.
Karolinska Institute.
Karolinska Institute.
Linköping University, Department of Medical and Health Sciences, Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.
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2011 (English)In: Birth Defects Research. Part C: Embryo Today Reviews, ISSN 1542-975X, Vol. 93, no 2, 182-193 p.Article, review/survey (Refereed) Published
Abstract [en]

Most in vivo preclinical disease models are based on mouse and other mammalian systems. However, these rodent-based model systems have considerable limitations to recapitulate clinical situations in human patients. Zebrafish have been widely used to study embryonic development, behavior, tissue regeneration, and genetic defects. Additionally, zebrafish also provides an opportunity to screen chemical compounds that target a specific cell population for drug development. Owing to the availability of various genetically manipulated strains of zebrafish, immune privilege during early embryonic development, transparency of the embryos, and easy and precise setup of hypoxia equipment, we have developed several disease models in both embryonic and adult zebrafish, focusing on studying the role of angiogenesis in pathological settings. These zebrafish disease models are complementary to the existing mouse models, allowing us to study clinically relevant processes in cancer and nonmalignant diseases, which otherwise would be difficult to study in mice. For example, dissemination and invasion of single human or mouse tumor cells from the primary site in association with tumor angiogenesis can be studied under normoxia or hypoxia in zebrafish embryos. Hypoxia-induced retinopathy in the adult zebrafish recapitulates the clinical situation of retinopathy development in diabetic patients or age-related macular degeneration. These zebrafish disease models offer exciting opportunities to understand the mechanisms of disease development, progression, and development of more effective drugs for therapeutic intervention.

Place, publisher, year, edition, pages
John Wiley and Sons.Ltd , 2011. Vol. 93, no 2, 182-193 p.
Keyword [en]
zebrafish; angiogenesis; cancer; metastasis; retinopathy; hypoxia
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-69886DOI: 10.1002/bdrc.20203ISI: 000291545600007OAI: diva2:433311
Available from: 2011-08-09 Created: 2011-08-08 Last updated: 2014-01-14

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Dahl Jensen, LasseLänne, TosteWahlberg, Eric
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CardiologyFaculty of Health SciencesPhysiologyDepartment of Thoracic and Vascular SurgeryVascular surgeryDepartment of Thoracic and Vascular Surgery
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ReferencesLink to record
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