liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Early drug discovery and the rise of pharmaceutical chemistry
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Drug Research.
2011 (English)In: DRUG TESTING AND ANALYSIS, ISSN 1942-7603, Vol. 3, no 6, 337-344 p.Article in journal (Refereed) Published
Abstract [en]

Studies in the field of forensic pharmacology and toxicology would not be complete without some knowledge of the history of drug discovery, the various personalities involved, and the events leading to the development and introduction of new therapeutic agents. The first medicinal drugs came from natural sources and existed in the form of herbs, plants, roots, vines and fungi. Until the mid-nineteenth century natures pharmaceuticals were all that were available to relieve mans pain and suffering. The first synthetic drug, chloral hydrate, was discovered in 1869 and introduced as a sedative-hypnotic; it is still available today in some countries. The first pharmaceutical companies were spin-offs from the textiles and synthetic dye industry and owe much to the rich source of organic chemicals derived from the distillation of coal ( coal-tar). The first analgesics and antipyretics, exemplified by phenacetin and acetanilide, were simple chemical derivatives of aniline and p-nitrophenol, both of which were byproducts from coal-tar. An extract from the bark of the white willow tree had been used for centuries to treat various fevers and inflammation. The active principle in white willow, salicin or salicylic acid, had a bitter taste and irritated the gastric mucosa, but a simple chemical modification was much more palatable. This was acetylsalicylic acid, better known as Aspirin., the first blockbuster drug. At the start of the twentieth century, the first of the barbiturate family of drugs entered the pharmacopoeia and the rest, as they say, is history.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2011. Vol. 3, no 6, 337-344 p.
Keyword [en]
alkaloids; analgesics; barbiturates; drugs; discovery; plants; natural products; pharmacology
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-69880DOI: 10.1002/dta.301ISI: 000292195300001OAI: diva2:433320
Available from: 2011-08-09 Created: 2011-08-08 Last updated: 2014-06-11

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Jones, A Wayne
By organisation
Faculty of Health SciencesDivision of Drug Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 43 hits
ReferencesLink to record
Permanent link

Direct link