liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Scandinavian glutamine trial: a pragmatic multi-centre randomised clinical trial of intensive care unit patients
Karolinska University Hospital.
Karolinska University Hospital.
Sahlgrens University Hospital.
Kristianstad Hospital.
Show others and affiliations
2011 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 55, no 7, 812-818 p.Article in journal (Refereed) Published
Abstract [en]

Background: Low plasma glutamine concentration is an independent prognostic factor for an unfavourable outcome in the intensive care unit (ICU). Intravenous (i.v.) supplementation with glutamine is reported to improve outcome. In a multi-centric, double-blinded, controlled, randomised, pragmatic clinical trial of i.v. glutamine supplementation for ICU patients, we investigated outcomes regarding sequential organ failure assessment (SOFA) scores and mortality. The hypothesis was that the change in the SOFA score would be improved by glutamine supplementation. Methods: Patients (n = 413) given nutrition by an enteral and/or a parenteral route with the aim of providing full nutrition were included within 72 h after ICU admission. Glutamine was supplemented as i.v. L-alanyl-L-glutamine, 0.283 g glutamine/kg body weight/24 h for the entire ICU stay. Placebo was saline in identical bottles. All included patients were considered as intention-to-treat patients. Patients given supplementation for greater than3 days were considered as predetermined per protocol (PP) patients. Results: There was a lower ICU mortality in the treatment arm as compared with the controls in the PP group, but not at 6 months. For change in the SOFA scores, no differences were seen, 1 (0,3) vs. 2 (0.4), P = 0.792, for the glutamine group and the controls, respectively. Conclusion: In summary, a reduced ICU mortality was observed during i.v. glutamine supplementation in the PP group. The pragmatic design of the study makes the results representative for a broad range of ICU patients.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2011. Vol. 55, no 7, 812-818 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-69777DOI: 10.1111/j.1399-6576.2011.02453.xISI: 000292649500007OAI: diva2:433603
Available from: 2011-08-10 Created: 2011-08-08 Last updated: 2012-03-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sjöberg, Folke
By organisation
Burn CenterFaculty of Health SciencesDepartment of Plastic Surgery, Hand surgery UHLDepartment of Anaesthesiology and Surgery UHL
In the same journal
Acta Anaesthesiologica Scandinavica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 53 hits
ReferencesLink to record
Permanent link

Direct link