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Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)
Clermont Université, Université d'Auvergne, EA 3295, Equipe de recherche en signal et imagerie médicale, Image- Guided Clinical Neuroscience and Connectomics (IGCNC), BP 10448, F-63000 Clermont-Ferrand, France/CHU Clermont-Ferrand, Service de Neurochirurgie, F-63003 Clermont-Ferrand, France.
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. (MINT)ORCID iD: 0000-0002-0012-7867
2012 (English)In: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 50, no 1, 23-32 p.Article in journal (Refereed) Published
Abstract [en]

The aim was to quantify the influence of heterogeneous isotropic and heterogeneous anisotropic tissue on the spatial distribution of the electric field during deep brain stimulation (DBS). Three finite element tissue models were created of one patient treated with DBS. Tissue conductivity was modelled as I) homogeneous isotropic, II) heterogeneous isotropic based on MRI, and III) heterogeneous anisotropic based on diffusion tensor MRI. Modelled DBS electrodes were positioned in the subthalamic area, the pallidum, and the internal capsule in each tissue model. Electric fields generated during DBS were simulated for each model and target-combination and visualized in 3D with isolevels at 0.20 (inner), and 0.05 V m-1 (outer). F-test and vector analysis was used for statistical evaluation of the distribution of the electric field. Heterogeneous isotropic tissue altered the spatial distribution of the electric field by up to 4% at inner, and up to 10% at outer isolevel. Heterogeneous anisotropic tissue had a larger impact on the distribution of the electric field with an influence of up to 18% and 15% at each isolevel, respectively. The influence of heterogeneous and anisotropic tissue on the electric field may be clinically relevant in anatomic regions that are functionally subdivided and surrounded by multiple fibres of passage.

Place, publisher, year, edition, pages
Springer, 2012. Vol. 50, no 1, 23-32 p.
Keyword [en]
Deep brain stimulation, Diffusion tensor, Finite element, Model, Simulation, Patient-specific
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-70087DOI: 10.1007/s11517-011-0842-zISI: 000298648400003OAI: oai:DiVA.org:liu-70087DiVA: diva2:435386
Note

funding agencies|Swedish Foundation for Strategic Research (SSF)||Swedish Research Council (VR)| 621-2008-3013 |Swedish Governmental Agency for Innovation Systems (VINNOVA)| 311-2006-7661 |

Available from: 2011-08-18 Created: 2011-08-18 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Modelling, Simulaltion, and Visualization of Deep Brain Stimulation
Open this publication in new window or tab >>Modelling, Simulaltion, and Visualization of Deep Brain Stimulation
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Deep brain stimulation (DBS) is an effective surgical treatment for neurological diseases such as essential tremor, Parkinsonʹs disease (PD) and dystonia. DBS has so far been used in more than 70 000 patients with movement disorders, and is currently in trial for intractable Gilles de la Tourette’s syndrome, obsessive compulsive disorders, depression, and epilepsy. DBS electrodes are implanted with stereotactic neurosurgical techniques in the deep regions of the brain. Chronic electrical stimulation is delivered to the electrodes from battery-operated pulse generators that are implanted below the clavicle.

The clinical benefit of DBS is largely dependent on the spatial distribution of the electric field in relation to brain anatomy. To maximize therapeutic benefits while avoiding unwanted side-effects, knowledge of the distribution of the electric field in relation anatomy is essential. Due to difficulties in measuring electric fields in vivo, computerized analysis with finite element models have emerged as an alternative.

The aim of the thesis was to investigate technical and clinical aspects of DBS by means of finite element models, simulations, and visualizations of the electric field and tissue anatomy. More specifically the effects of dilated perivascular spaces filled with cerebrospinal fluid on the electrical field generated by DBS was evaluated. A method for patient-specific finite element modelling and simulation of DBS was developed and used to investigate the anatomical distribution of the electric field in relation to clinical effects and side effects. Patient-specific models were later used to investigate the electric field in relation to effects on speech and movement during DBS in patients with PD (n=10). Patient-specific models and simulations were also used to evaluate the influence of heterogeneous isotropic and heterogeneous anisotropic tissue on the electric field during DBS. In addition, methods were developed for visualization of atlas-based and patient-specific anatomy in 3D for interpretation of anatomy, visualization of neural activation with the activating function, and visualization of tissue micro structure. 3D visualization of anatomy was used to assess electrode contact locations in relation to stimulation-induced side-effects (n=331) during DBS for patients with essential tremor (n=28). The modelling, simulation, and visualization of DBS provided detailed information about the distribution of the electric field and its connection to clinical effects and side-effects of stimulation. In conclusion, the results of this thesis provided insights that may help to improve DBS as a treatment for movement disorders as well as for other neurological diseases in the future.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2011. 84 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1384
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-70090 (URN)978-91-7393-114-4 (ISBN)
Public defence
2011-09-09, Eken, Campus US, Linköpings universitet, Linköping, 09:00 (English)
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Supervisors
Available from: 2011-08-18 Created: 2011-08-18 Last updated: 2017-02-09Bibliographically approved

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Åström, MattiasWårdell, Karin

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