IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors
2011 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 118, no 5, 1283-1290 p.Article in journal (Refereed) Published
eficiencies in the IL-7 signaling pathway result in severe disruptions of lymphoid development in adult mice. To understand more about how IL-7 deficiency impacts early lymphoid development, we have investigated lineage restriction events within the common lymphoid progenitor (CLP) compartment in IL-7 knockout mice. This revealed that although IL-7 deficiency had a minor impact on the development of LY6D(-) multipotent CLPs, the formation of the lineage restricted LY6D(+) CLP population was dramatically reduced. This was reflected in a low-level transcription of B-lineage genes as well as in a loss of functional B-cell commitment. The few Ly6D(+) CLPs developed in the absence of IL-7 displayed increased lineage plasticity and low expression of Ebf-1. Absence of Ebf-1 could be linked to increased plasticity because even though Ly6D(+) cells develop in Ebf-1-deficient mice, these cells retain both natural killer and dendritic cell potential. This reveals that IL-7 is essential for normal development of Ly6D(+) CLPs and that Ebf-1 is crucial for lineage restriction in early lymphoid progenitors.
Place, publisher, year, edition, pages
American Society of Hematology , 2011. Vol. 118, no 5, 1283-1290 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-70104DOI: 10.1182/blood-2011-01-332189ISI: 000293510000020OAI: oai:DiVA.org:liu-70104DiVA: diva2:435548