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Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction
University of Groningen.
University of Groningen.
University of Groningen.
University of Groningen.
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2011 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 13, no 9, 1013-1018 p.Article in journal (Refereed) Published
Abstract [en]

Aims To compare quality of life (QoL) in heart failure (HF) patients with preserved ejection fraction (HF-PEF) and HF patients with reduced ejection fraction (HF-REF) in a well-defined HF population. less thanbrgreater than less thanbrgreater thanMethods and results Patients with HF-PEF [left ventricular ejection fraction (LVEF) andgt;= 40%] were matched by age and gender to patients with HF-REF (LVEF,40%). In the current study, we only included HF patients with a B-type natriuretic peptide level (BNP) andgt; 100 pg/mL. Quality of life was assessed by Cantrils Ladder of Life, RAND-36, and the Minnesota Living with Heart Failure questionnaire, and impairment of QoL was adjusted for by BNP as a marker for severity of HF. We examined a total of 290 HF patients, of whom 145 had HF-PEF (41% female; age 72 +/- 10; LVEF 51 +/- 8%) and 145 had HF-REF (41% female; age 73 +/- 10, LVEF 26 +/- 7%). All HF patients reported markedly low scores of QoL, both on the general and disease-specific QoL questionnaires. Quality of life between patients with HF-PEF and HF-REF did not differ significantly. When adjusting the QoL scores for BNP, an association between QoL and LVEF was not found, i.e. patients with HF-PEF and HF-REF with similar BNP levels had the same impairment in QoL. less thanbrgreater than less thanbrgreater thanConclusion Quality of life is similarly impaired in patients with HF-PEF as in HF-REF. These findings further support the need for more pharmacological and non-pharmacological studies in patients with HF-PEF.

Place, publisher, year, edition, pages
Oxford University Press (OUP) , 2011. Vol. 13, no 9, 1013-1018 p.
Keyword [en]
Heart failure, Quality of life, Preserved ejection fraction, Reduced ejection fraction, B-type Natriuretic Peptide
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-70519DOI: 10.1093/eurjhf/hfr072ISI: 000294070800014OAI: diva2:440107
|Biosite Europe||Amgen||Pfizer||Medtronic||Biotronic||Alere||Vifor||Available from: 2011-09-12 Created: 2011-09-12 Last updated: 2011-09-20

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Jaarsma, Tiny
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