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Corneal implantation with collagen-copolymer matrices
University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
National Research Council Canada, Ottawa, Ontario Canada.
Universitäts-Augenklink, University of Regensburg, Regensburg, Germany.
University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
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2005 (English)In: Key Engineering Materials, ISSN 1013-9826, E-ISSN 1662-9795, Vol. 288-289, 389-392 p.Article in journal (Refereed) Published
Abstract [en]

A transparent matrix composed of collagen and poly(N, N-dimethylacrylamide-coacryloxysuccimide), 8mm in diameter and 350 mu m thick was implanted into pigs corneas using the lamellar keratoplasty (LKP) technique. No adverse immune or inflammatory reaction was observed during 4 month implantation period. Regenerated nerve filaments were observed in the subepithelial region and stroma by confacal microscopy. The endothelium of the operated eye was not touched by LKP and remained similar to that of the contra lateral (not operated) eye. The implant remained transparent over the four-month post-operative period, and clinical topography showed reconstitution of a smooth cornea surface. These preliminary results indicated that a new, functional cornea was re-established from the implanted biosynthetic matrix. This bio-synthetic matrix may have applications in other tissue engineering areas,, especially where innervation is important.

Place, publisher, year, edition, pages
Trans Tech Publications , 2005. Vol. 288-289, 389-392 p.
Keyword [en]
artificial cornea; hydrogel; corneal implant; collagen; collagen composite
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-70669DOI: 10.4028/www.scientific.net/KEM.288-289.389ISI: 000230426600095OAI: oai:DiVA.org:liu-70669DiVA: diva2:441041
Available from: 2011-09-14 Created: 2011-09-14 Last updated: 2017-12-08

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