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Bioengineered corneas for transplantation and in vitro toxicology
University of Ottawa Eye Inst., Ottawa, ON, Canada and Department of Cellular and Molecular Medicine, Univ. of Ottawa, Ottawa, ON, Canada.
Taipei Eye Center, Taipei Medical University, Taipei, Taiwan.
University of Ottawa Eye Inst., Ottawa, ON, Canada and Department of Physics, Univ. of Ottawa, Ottawa ON, Canada.
University of Ottawa Eye Inst., Ottawa, ON, Canada and Department of Cellular and Molecular Medicine, Univ. of Ottawa, Ottawa, ON, Canada.ORCID iD: 0000-0003-1222-6720
2009 (English)In: Frontiers in Bioscience, ISSN 1093-9946, E-ISSN 1093-4715, Vol. 14, 3326-3337 p.Article in journal (Refereed) Published
Abstract [en]

Bioengineered corneas have been designed to replace partial or the full-thickness of defective corneas, as an alternative to using donor tissues. They range from prosthetic devices that solely address replacement of the corneas function, to tissue engineered hydrogels that permit regeneration of host tissues. In cases where corneal stem cells have been depleted by injury or disease, most frequently involving the superficial epithelium, tissue engineered lamellar implants reconstructed with stem cells have been transplanted. In situ methods using ultraviolet A (UVA) crosslinking have also been developed to strengthen weakened corneas. In addition to the clinical need, bioengineered corneas are also rapidly gaining importance in the area of in vitro toxicology, as alternatives to animal testing. More complex, fully innervated, physiologically active, three-dimensional organotypic models are also being tested.

Place, publisher, year, edition, pages
Frontiers in Bioscience , 2009. Vol. 14, 3326-3337 p.
Keyword [en]
3D; Artificial; Biomimetic; Collagen; Cornea; Crosslinking; ECM; Extracellular Matrix; Innervation; In situ; In vitro; Keratoprosthesis; PHEMA; PMMA; Recombinant; Review; Scaffold; Stem Cells; Tissue Engineering; Toxicology; Review
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-70663DOI: 10.2741/4055ISI: 000262352400228OAI: oai:DiVA.org:liu-70663DiVA: diva2:441073
Available from: 2011-09-14 Created: 2011-09-14 Last updated: 2017-12-08

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Griffith, May

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