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Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID iD: 0000-0003-1222-6720
University of Ottawa Eye Institute and Ottawa Health Research Institute, Ottawa, ON, Canada.
2008 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 19, no 11, 3365-3371 p.Article in journal (Refereed) Published
Abstract [en]

A composite collagen hydrogel containing protein encapsulated alginate microspheres was developed for ocular applications. Bovine serum albumin (BSA) served as a drug model. The composite hydrogel retained optical clarity and mechanical robustness of control hydrogels without microspheres. A sustained release of BSA was achieved during an 11-day period in neutral phosphate buffer. The composite hydrogel supported human corneal epithelial cell growth and had adequate mechanical strength and excellent optical clarity for possible use as therapeutic lens for drug delivery and/or use as corneal substitute for transplantation into patients who have corneal diseases.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2008. Vol. 19, no 11, 3365-3371 p.
National Category
Engineering and Technology
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URN: urn:nbn:se:liu:diva-70660DOI: 10.1007/s10856-008-3486-2ISI: 000259127200007OAI: oai:DiVA.org:liu-70660DiVA: diva2:441078
Available from: 2011-09-14 Created: 2011-09-14 Last updated: 2017-12-08

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