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Recruitment of multiple cell lines by collagen-synthetic copolymer matrices in corneal regeneration
University of Ottawa Eye Institute and National Research Council, Ottawa, Canada.
University of Ottawa Eye Institute, Ottawa, Canada.ORCID iD: 0000-0003-1222-6720
National Research Council, Ottawa, Canada.
National Research Council, Ottawa, Canada and National Science and Technology Development Center, Pathumthani, Thailand.
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2005 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 26, no 16, 3093-3104 p.Article in journal (Refereed) Published
Abstract [en]

Collagen hydrogel matrices with high optical clarity have been developed from collagen 1, cross-linked with a copolymer based on N-isopropylacrylamide, acrylic acid and acryloxysuccinimide. The controlled reaction of collagen amine groups with this copolymer under neutral pH and aqueous conditions gave robust, optically clear hydrogels and prevented the excessive collagen fibrillogenesis that can lead to collagen opacity. These sterile, non-cytotoxic hydrogels allowed epithelial cell overgrowth and both stromal cell and nerve neurite ingrowth from the host tissue. This regenerative ability appeared to result from the high glucose permeability, nanoporosity and the presence of cell adhesion factors, RGD in collagen and the laminin pentapeptide, YIGSR, grafted onto the copolymer. Under physiological conditions, optical clarity superior to the human cornea and tensile performance adequate for suturing were obtained from some formulations. (C) 2004 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier , 2005. Vol. 26, no 16, 3093-3104 p.
Keyword [en]
collagen-copolymer hydrogel; cell recruitment; permeability; porosity; topography; optical clarity
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-70692DOI: 10.1016/j.biomaterials.2004.07.063ISI: 000226675500031OAI: diva2:441089
Available from: 2011-09-14 Created: 2011-09-14 Last updated: 2013-12-17

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Griffith, M
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