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Promotion of angiogenesis in tissue engineering: Developing multicellular matrices with multiple capacities
Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada.
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
Oncology and Molecular Endocrinology Research Center CHUL and Laval University, Quebec City, Canada.
Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada.
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2006 (English)In: International Journal of Artificial Organs, ISSN 0391-3988, E-ISSN 1724-6040, Vol. 29, no 12, 1148-1157 p.Article in journal (Refereed) Published
Abstract [en]

One of the aims of tissue engineering is to be able to develop multi-tissue organs in the future. This requires the optimization of conditions for the differentiation of multiple cell types and maintenance of the differentiated phenotype within complex engineered tissues. The goal of this study was to develop prototype tissue engineered matrices to support the simultaneous growth of different cell types with a particular focus on the angiogenic process. We examined two different matrix compositions for the promotion of blood vessel and tube formation. A fibrin-based matrix with the addition of a combination of growth factors supported vascular growth and the invasion of inflammatory cells. Using this fibrin matrix, in combination with a collagen-based hydrogel, a simple in vitro model of the cornea with adjacent sclera was developed that was complete with innervation and vascular structures. In addition, we showed that collagen-based matrices were effective in delivering mononuclear endothelial progenitor cells to ischemic tissue in vivo, and allowing these cells to incorporate into vascular structures. It is anticipated that with further development, these matrices have potential for use as delivery matrices for cell transplantation and for in vitro study purposes of multiple cell types.

Place, publisher, year, edition, pages
Wichtig Editore , 2006. Vol. 29, no 12, 1148-1157 p.
Keyword [en]
tissue engineering; angiogenesis; artificial organs; extracellular matrix
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-70690ISI: 000243963700008OAI: diva2:441091
Available from: 2011-09-14 Created: 2011-09-14 Last updated: 2013-12-17

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Griffith, M.
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