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Plasma surface modification and characterization of collagen-based artificial cornea for enhanced epithelialization
Department of Chemical Engineering, University of Ottawa and University of Ottawa Eye Institute, Ottawa, Ontario, Canada.ORCID iD: 0000-0001-6024-4144
University of Ottawa Eye Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.ORCID iD: 0000-0003-1222-6720
Department of Chemical Engineering, University of Ottawa and University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
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2007 (English)In: Journal of Applied Polymer Science, ISSN 0021-8995, E-ISSN 1097-4628, Vol. 106, no 3, 2056-2064 p.Article in journal (Refereed) Published
Abstract [en]

Argon plasma treatment enhanced the attachment of epithelial cells to a collagen-based artificial cornea crosslinked using glutaraldehyde (GA) and glutaraldehyde-polyethylene oxide dialdehyde (GA-PEODA) systems. The epithelialization of untreated and treated surfaces was evaluated by the seeding and growth of human corneal epithelial cells. Characterization of polymer surface properties such as surface hydrophilicity and roughness was also made by contact angle measurement and atomic force microscopy, respectively. Contact angle analysis revealed that the surface hydrophilicity significantly increased after the treatment. In addition, AFM characterization showed an increase in surface roughness through argon plasma treatment. Based on the biological and surface analysis, argon plasma treatment displays promising potential for biocompatibility enhancement of collagen-based artificial corneas. It was also found that the cell attachment to artificial cornea surfaces was influenced by the combined effects of surface chemistry (i.e., surface energy), polymer surface morphology (i.e., surface roughness), and polar interactions between functional groups at the polymer surface and cell membrane proteins.

Place, publisher, year, edition, pages
Wiley-Blackwell , 2007. Vol. 106, no 3, 2056-2064 p.
Keyword [en]
atomic force microscopy; biocompatibility; crosslinking; modification; plasma
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-70689DOI: 10.1002/app.25305ISI: 000249312000079OAI: oai:DiVA.org:liu-70689DiVA: diva2:441094
Available from: 2011-09-14 Created: 2011-09-14 Last updated: 2017-12-08Bibliographically approved

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Rafat, MehrdadGriffith, May

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