Effect of chronic mild stress on skin and brain in the NC/Nga atopic-like mouse
2011 (English)In: JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol 131 Issue S2 (September 2011): Satellite Meeting at ESDR 2011: Abstracts from Neurobiology of the Skin Symposium, Nature Publishing Group , 2011, Vol. 131, S116-S116 p.Conference paper (Refereed)
Atopic eczema is often worsened by stress. We have studied the effect of chronic mild stress in the atopic-like NC/Nga mouse strain. The mice were subjected to chronic mild stress for 12 weeks and eczema was induced by applying a mite antigen (Dermatophagoides pteronyssinus) on the ears for the last 4 weeks. The mice were divided into stressed eczematous, non-stressed eczematousand stressed control groups. Serum corticosterone levels were determined at the endpoint of the experiment. The biopsies from skin and brain have been analyzed using immunohistochemistry and RT-PCR. The diameter of the ears was larger in the stressed eczematous group compared to the other groups. Moreover, the corticosterone levels were significantly lower in the stressedeczematous group. The neuromediators being studied are serotonin, its transporter protein, as well as its receptors, and the tachykinin substance P and its receptor neurokinin-1.
Place, publisher, year, edition, pages
Nature Publishing Group , 2011. Vol. 131, S116-S116 p.
National CategoryEngineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-70740DOI: 10.1038/jid.2011.216ISI: 000294361300683OAI: oai:DiVA.org:liu-70740DiVA: diva2:441422
41st Annual ESDR, 7–10 September 2011 Barcelona, Spain