Molecular characterization of the interaction between the disordered c-Myc transactivation domain and the TATA-binding protein (TBP)
(English)Manuscript (preprint) (Other academic)
The proto-oncogene c-myc affects the occurrence, expansion, and evolution of numerous aggressive human cancers, and is often associated with the late-stage and/or poor prognostic disease. Regulation of target gene activity by c-Myc occurs through protein interactions with the c-Myc transactivation domain (TAD) which, in addition to binding the TATA-binding protein (TBP) also recruits a wide variety of co-activators and suppressor proteins. Here, we present a molecular model, based on NMR, X-ray crystallography and SPR measurements, which describes how the c-Myc TAD binds to TBP. Our model contributes to the understanding of how c-Myc can regulate individual genes as well as entire gene programs.
IdentifiersURN: urn:nbn:se:liu:diva-70833OAI: oai:DiVA.org:liu-70833DiVA: diva2:441975