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Where did bone come from? An overview of its evolution
Free University of Berlin.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
2011 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 82, no 4, 393-398 p.Article in journal (Refereed) Published
Abstract [en]

Bone is specific to vertebrates, and originated as mineralization around the basal membrane of the throat or skin, giving rise to tooth-like structures and protective shields in animals with a soft cartilage-like endoskeleton. A combination of fossil anatomy and genetic information from modern species has improved our understanding of the evolution of bone. Thus, even in man, there are still similarities in the molecular regulation of skin append-ages and bone. This article gives a brief overview of the major milestones in skeletal evolution. Some molecular machineries involving members of core genetic networks and their interactions are described in the context of both old theories and modern genetic approaches.

Place, publisher, year, edition, pages
Informa Healthcare , 2011. Vol. 82, no 4, 393-398 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-71096DOI: 10.3109/17453674.2011.588861ISI: 000294851100001OAI: diva2:444820
Available from: 2011-09-30 Created: 2011-09-30 Last updated: 2011-11-17

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Aspenberg, Per
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Orthopaedics and Sports MedicineFaculty of Health SciencesDepartment of Orthopaedics in Linköping
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