Where did bone come from? An overview of its evolution
2011 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 82, no 4, 393-398 p.Article in journal (Refereed) Published
Bone is specific to vertebrates, and originated as mineralization around the basal membrane of the throat or skin, giving rise to tooth-like structures and protective shields in animals with a soft cartilage-like endoskeleton. A combination of fossil anatomy and genetic information from modern species has improved our understanding of the evolution of bone. Thus, even in man, there are still similarities in the molecular regulation of skin append-ages and bone. This article gives a brief overview of the major milestones in skeletal evolution. Some molecular machineries involving members of core genetic networks and their interactions are described in the context of both old theories and modern genetic approaches.
Place, publisher, year, edition, pages
Informa Healthcare , 2011. Vol. 82, no 4, 393-398 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-71096DOI: 10.3109/17453674.2011.588861ISI: 000294851100001OAI: oai:DiVA.org:liu-71096DiVA: diva2:444820