liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Left and right ventricular function in aortic stenosis patients 8 weeks post-transcatheter aortic valve implantation or surgical aortic valve replacement
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Clinical Physiology UHL.
Linköping University, Department of Medical and Health Sciences, Thoracic Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Thoracic and Vascular Surgery in Östergötland.
Linköping University, Department of Medical and Health Sciences, Thoracic Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Thoracic and Vascular Surgery in Östergötland.
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Cardiology UHL.
Show others and affiliations
2011 (English)In: European Journal of Echocardiography, ISSN 1525-2167, E-ISSN 1532-2114, Vol. 12, no 8, 603-611 p.Article in journal (Refereed) Published
Abstract [en]

Aims Knowledge of longitudinal left and right ventricular (LV and RV) function after transcatheter aortic valve implantation (TAVI) is scarce. We hypothesized that the longitudinal systolic biventricular function in aortic stenosis (AS) patients is affected differently by TAVI and surgical aortic valve replacement (SAVR). less thanbrgreater than less thanbrgreater thanMethods and results Thirty-three AS patients (all-TAVI group, age 81 +/- 9 years, 18 female), with EuroSCORE 18 +/- 9%, were accepted for TAVI. Seventeen of these patients were matched (by gender, age, and LV function) to 17 patients undergoing SAVR. Conventional echocardiographic parameters, systolic atrioventricular plane displacement (AVPD) at standard sites and peak systolic velocity (PSV) by pulsed tissue Doppler at basal RV free wall, LV lateral wall, and septum were studied before and 8 weeks after the procedure. Procedural success was 100%, and 30-day mortality 9%. In all TAVI patients, AVPD(lateral), PSV(lateral), AVPD(septal), and PSV(septal) increased (P andlt; 0.001, 0.003, 0.006 and 0.002). When studying the matched patients postoperatively, both the SAVR and TAVI patients had increased PSV(lateral) and AVPD(lateral) (SAVR: P = 0.03 and P = 0.04, TAVI: P = 0.04 and P = 0.01). The PSV(RV) increased in the all-TAVI group (P = 0.007), while the AVPD(RV) was unchanged. SAVR patients had decreased AVPD(RV) (P = 0.001) and PSV(RV) (P = 0.004), while the matched TAVI patients had unchanged RV function parameters. less thanbrgreater than less thanbrgreater thanConclusion An improvement in regional longitudinal LV function in the septal and lateral wall could be seen after TAVI. Among the matched patients, both the TAVI and SAVR patients seemed to improve LV function in the lateral wall. RV systolic function increased in TAVI patients, but was impaired in the matched SAVR group at the 8-week follow-up.

Place, publisher, year, edition, pages
Oxford University Press (OUP) , 2011. Vol. 12, no 8, 603-611 p.
Keyword [en]
Transcatheter aortic valve implantation, Aortic stenosis, Left ventricular function, Right ventricular function, Echocardiography
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-71089DOI: 10.1093/ejechocard/jer085ISI: 000294861700006OAI: oai:DiVA.org:liu-71089DiVA: diva2:444826
Note

Funding Agencies|Swedish Heart Lung Foundation||Medical Research Council of Southeast Sweden||County Council of Ostergotland, Sweden||

Available from: 2011-09-30 Created: 2011-09-30 Last updated: 2017-12-08
In thesis
1. Cardiac Function and Aortic Valve Intervention: Echocardiographic Studies of Myocardial Recovery in Patients with Severe Aortic Valve Disease
Open this publication in new window or tab >>Cardiac Function and Aortic Valve Intervention: Echocardiographic Studies of Myocardial Recovery in Patients with Severe Aortic Valve Disease
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In patients with severe aortic valve disease, aortic valve intervention is performed when the risk for mortality or morbidity with conservative management is significantly increased. Left ventricular (LV) longitudinal motion decreases before conventional echocardiographic measures such as ejection fraction, are influenced in patients with severe aortic valve disease. This thesis is devoted to the assessment of cardiac function, including ventricular longitudinal motion, by echocardiography before and after aortic valve intervention in patients with chronic severe aortic regurgitation (AR) or severe aortic stenosis (AS).

Patients with chronic AR (n=29) were studied preoperatively, and 6 months and 4 years postoperatively by echocardiography, including tissue Doppler imaging, at rest and during exercise. LV longitudinal function (atrioventricular plane displacement, AVPD, and peak systolic velocity, PSV) decreased postoperatively, and patients with low PSV continued to show reduced longitudinal function 6 months after surgery. Preoperative exercise echocardiographic variables showed a strong correlation to late LV function variables, while preoperative variables obtained at rest were not useful for prediction. Exercise echocardiography and longitudinal LV function could therefore be useful complements in the timing of aortic valve surgery for AR.

Patients with chronic AR (n=29) were studied preoperatively, and 6 months and 4 years postoperatively by echocardiography, including tissue Doppler imaging, at rest and during exercise. LV longitudinal function (atrioventricular plane displacement, AVPD, and peak systolic velocity, PSV) decreased postoperatively, and patients with low PSV continued to show reduced longitudinal function 6 months after surgery. Preoperative exercise echocardiographic variables showed a strong correlation to late LV function variables, while preoperative variables obtained at rest were not useful for prediction. Exercise echocardiography and longitudinal LV function could therefore be useful complements in the timing of aortic valve surgery for AR.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2012. 78 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1319
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-81051 (URN)978-91-7519-844-6 (ISBN)
Public defence
2012-09-28, Berzeliussalen, Hälsouniversitetet, Campus US, Linköpings Universitet, Linköping, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2012-09-06 Created: 2012-09-06 Last updated: 2012-09-06Bibliographically approved

Open Access in DiVA

fulltext(569 kB)503 downloads
File information
File name FULLTEXT01.pdfFile size 569 kBChecksum SHA-512
094a90582418fd521b671d7f3c8a6b5f0605b101ba19f19661f4243e589020953bdc621f8a895580c560b29e7b3d606d712c45861303085b678d4c5f94b9d408
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Forsberg, Lena MTamas, EvaVánky, FarkasNielsen, Niels ErikEngvall, JanNylander, Eva

Search in DiVA

By author/editor
Forsberg, Lena MTamas, EvaVánky, FarkasNielsen, Niels ErikEngvall, JanNylander, Eva
By organisation
Clinical PhysiologyFaculty of Health SciencesDepartment of Clinical Physiology UHLThoracic SurgeryDepartment of Thoracic and Vascular Surgery in ÖstergötlandCardiologyDepartment of Cardiology UHLCenter for Medical Image Science and Visualization, CMIV
In the same journal
European Journal of Echocardiography
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 503 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 375 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf