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DaTSCAN SPECT EVALUATION OF PATIENTS WITH MOVEMENT DISORDERS
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
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2011 (English)In: EUROPEAN JOURNAL OF NEUROLOGY, Wiley-Blackwell, 2011, Vol. 18 (Suppl. 2), no SI, 567-567 p., P2617Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Introduction: Molecular imaging with DaTSCAN SPECTis widely used as a diagnostic tool in patients with movementdisorders in the form of Parkinson's Disease (PD),Parkinson-plus syndromes and Tremor. In the present studythe potency of DATScan SPECT to detect degeneration inthe basal ganglia in early stages of PD, before the onset ofmedication, is evaluated. In addition the efficacy ofDaTSCAN for differential diagnosis between patients withidiopathic PD and patients with Parkinson-plus syndromesis examined.

Methodology: Participants: 21 patients with PD in earlystages, before the onset of medication, 20 patients withidiopathic PD and 6 patients with Parkinson-plussyndromes. 15 participants with normal results ofDaTSCAN SPECT and a clinical diagnosis different fromPD or Parkinson-plus were used as control.

DaTSCAN SPECT: In the present study the quantificationof Striatum Occipital/Occipital and the Xeleris workstation(GE) were used.

Results: The quantification for patients with idiopathic PD(1.185±0.05687) was significantly lower (p<0.0001) fromthe control (2.369±0.1258) and significantly lower (p<0.05)from that of patients in early stages of PD, before the onsetof medication (1.359±0.05324). There was no significantdifference between the idiopathic PD and Parkinson-plussyndromes (1.103±0.2442).

Conclusion: DaTSCAN SPECT can detect efficiently earlydegeneration in the basal ganglia before the onset ofmedication is needed. Its efficacy for the differentialdiagnosis between idiopathic PD and Parkinson-plussyndromes is questioned. The combination of imaging andclinical examination is mandatory for a certain diagnosis.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2011. Vol. 18 (Suppl. 2), no SI, 567-567 p., P2617
Series
European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-71081DOI: 10.1111/j.1468-1331.2011.03552.xISI: 000294806601394OAI: oai:DiVA.org:liu-71081DiVA: diva2:444857
Conference
15th Congress of the European-Federation-of-Neurological-Societies (EFNS), Budapest, Hungary, September 10-13, 2011
Available from: 2011-09-30 Created: 2011-09-30 Last updated: 2017-06-19Bibliographically approved

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Georgiopoulos, CharalamposDavidsson, AnetteGranerus, GöranDizdar, NilZachrisson, Helene

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Georgiopoulos, CharalamposDavidsson, AnetteGranerus, GöranDizdar, NilZachrisson, Helene
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Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiology in LinköpingClinical PhysiologyFaculty of Health SciencesDepartment of Clinical Physiology in LinköpingDepartment of Clinical Chemistry
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