liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Electroactive Control of Platelet Adhesion to Conducting Polymer Micropatterns
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-2071-7768
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
Show others and affiliations
(English)Manuscript (preprint) (Other academic)
Abstract [en]

In this work, we report a method to fabricate addressable micropatterns of electroactive surfaces based on the conducting polymer poly-(3, 4-ethylenedioxytiophene) (PEDOT:Tos) to gain dynamic control over the spatial distribution of platelets, in vitro. Utilizing thin film processing and microfabrication techniques desired patterns down to the scale of  individual cells, were achieved to enable active regulation of cell  populations and their extracellular environment at high spatial resolution.Upon electronic addressing, both reduced and oxidized surfaces were created within the same device. The changes of the electrochemical state of PEDOT results in a reversible modification of the surface properties of the material. This surface modulation dictates the conformation and/or orientation, rather than the concentration, of surface proteins, thus indirectly regulating cell adhesion. The chemistry, texture, charge, and softness of fiacrtiial cell-hosting surfaces are parameters known to affect the binding characteristics and orientation of the extracellular proteins, thus dictating adhesion, spreading, migration, and proliferation of cells.

National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-71360OAI: oai:DiVA.org:liu-71360DiVA: diva2:447697
Available from: 2011-10-13 Created: 2011-10-13 Last updated: 2017-02-03Bibliographically approved
In thesis
1. Conjugated Polymer Surface Switches for Active Control
Open this publication in new window or tab >>Conjugated Polymer Surface Switches for Active Control
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Conjugated polymers have been found useful in a wide range of applications such as sensors, electrochemical transistors, solar cells, and printed electronics due to their mechanical, optical and electronic properties. An amazing research field has grown during the last three decades since the discovery of conducting polymers in 1976. Since the materials can be made from solutions, different processing methods such as spin coating and vapor phase polymerization can be used to coat a huge variety of substrates. The choice of method depends mainly on monomer solubility and kind of substrate to be coated. During the synthesis the polymers can be chemically modified to tailor their functionalities. Due to this variability in materials and the processability, electronics can be achieved on unconventional substrates such as flexible plastic foils and cell culturing dishes. As a contrast to inorganic, usually metallic materials, conducting polymers are built up from organic compounds in a molecular structure with soft mechanical properties that have shown to be a benefit in combination with biology, ranging from interactions with cells to interactions with advanced biological species such as tissues. This combination of research fields and the possible applications are merged within the field of organic bioelectronics.

The primary purpose of this thesis is to give a background to organic electronics in general and how electrochemical devices can be processed and developed for biological applications in particular. An organic electronic surface switch is introduced to control cell adhesion and proliferation as well as an electrochemical transistor to spatially tune the cell adhesion along an electrochemical gradient. To mimic a more natural cell environment a three dimensional fiber substrate was used to design an electronically active matrix to promote nerve cell adhesion and communication. By combining standard microfabrication techniques and conjugated polymers desired patterns of electroactive polymer were created to enable active regulation of cell populations and their extracellular environment at high spatial resolution. Finally, a brief look into future challenges will also be presented.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2011. 52 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1398
National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-71361 (URN)978-91-7393-063-5 (ISBN)
Public defence
2011-10-21, K3, Kåkenhus, Campus Norrköping, Linköpings universitet, Norrköping, 13:15 (English)
Opponent
Supervisors
Available from: 2011-10-13 Created: 2011-10-13 Last updated: 2017-02-03Bibliographically approved

Open Access in DiVA

No full text

Authority records BETA

Bolin, MariaFaxälv, LarsJager, EdwinLindahl, TomasBerggren, Magnus

Search in DiVA

By author/editor
Bolin, MariaFaxälv, LarsJager, EdwinLindahl, TomasBerggren, Magnus
By organisation
Department of Science and TechnologyThe Institute of TechnologyClinical ChemistryFaculty of Health SciencesDepartment of Clinical ChemistryPhysics and Electronics
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 147 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf