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A Randomized Trial Comparing 2 Doses of Polidocanol Sclerotherapy for Hydrocele or Spermatocele
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
Orebro University Hospital.
Sahlgrens University Hospital.
2011 (English)In: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 186, no 4, 1319-1323 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Polidocanol sclerotherapy for hydrocele or spermatocele combines high efficiency with low morbidity, but the optimal dose is not known. We compared the efficacy and morbidity of 2 or 4 ml polidocanol sclerotherapy for hydrocele or spermatocele. less thanbrgreater than less thanbrgreater thanMaterials and Methods: From 1993 to 2005 a double-blind randomized clinical trial was conducted using 2 or 4 ml polidocanol (30 mg/ml) for sclerotherapy of hydrocele/spermatocele in 224 evaluable patients at 3 university hospitals. Fluid was evacuated and 2 or 4 ml polidocanol was administered by a nurse, with the amount injected concealed from others present. At 3-month followup morbidity was ascertained using a questionnaire completed by the patients. Fluid recurrence was determined clinically and generally re-treated. less thanbrgreater than less thanbrgreater thanResults: After the first treatment, cure was observed in 59% and 47% in the 4 and the 2 ml group, respectively (p = 0.04). More patients in the 4 ml group had complications (31% vs 18%, p = 0.04). Complications were mostly of low or moderate intensity and seldom required medication. After 1 to 4 treatments 200 of 224 patients (89%) were cured and another 10 (5%) had small amounts of residual fluid, with no difference between the groups. Of the patients with hydroceles/spermatoceles larger than 175 ml, 58% and 34% were cured after the first treatment in the 4 and 2 ml groups, respectively (p = 0.012), with no differences in complications between the groups. less thanbrgreater than less thanbrgreater thanConclusions: Polidocanol sclerotherapy was effective for the treatment of hydrocele or spermatocele in our patients, with 94% satisfactory results after 1 to 4 treatments. A dose of 4 ml was superior to 2 ml, particularly for larger hydroceles/spermatoceles.

Place, publisher, year, edition, pages
Elsevier , 2011. Vol. 186, no 4, 1319-1323 p.
Keyword [en]
polidocanol, sclerotherapy, testicular hydrocele, spermatocele
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-71378DOI: 10.1016/j.juro.2011.06.005ISI: 000295399500042OAI: diva2:448066
Available from: 2011-10-14 Created: 2011-10-14 Last updated: 2011-10-14

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Jahnson, Staffan
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SurgeryFaculty of Health SciencesDepartment of Urology in Östergötland
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