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Glutathione in the blood and cerebrospinal fluid: A study in healthy male volunteers
Linköping University, Department of Clinical and Experimental Medicine, Psychiatry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Clinical Pathology and Clinical Genetics.ORCID iD: 0000-0003-4075-159X
2011 (English)In: Neuropeptides, ISSN 0143-4179, E-ISSN 1532-2785, Vol. 45, no 4, 287-292 p.Article in journal (Refereed) Published
Abstract [en]

Glutathione (GSH) is an important regulator of intracellular redox homeostasis. In the brain, glutathione is considered a major antioxidant, which is also found at high concentrations in the extracellular environment. Altered GSH balance in plasma, blood and cerebrospinal fluid (CSF) has been observed in several disorders suggesting that an impaired antioxidant function is part of the pathophysiology. The aim of the present study was to investigate a possible relationship between glutathione in plasma and CSF. Blood samples were collected from 26 healthy male volunteers at 8 a.m., noon, 4 p.m. and 8 p.m. At 8 a.m. the following morning, blood was drawn and three 6-ml fractions of CSF were collected by lumbar puncture. In CSF, a disrupted gradient was found showing the highest glutathione concentration in the second compared to the first and third fraction (P andlt; 0.002). Moreover, correlation and regression analyses between glutathione in plasma and CSF revealed an association between the third fraction CSF and plasma glutathione 8 p.m. the day before lumbar puncture. Thus, if carefully standardised due to the disrupted gradient in CSF, it might be possible to estimate glutathione levels in CSF by analysing plasma in healthy males.

Place, publisher, year, edition, pages
Elsevier , 2011. Vol. 45, no 4, 287-292 p.
Keyword [en]
Glutathione, Plasma, Blood, Cerebrospinal fluid, Lumbar puncture
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-71560DOI: 10.1016/j.npep.2011.05.004ISI: 000295349600005OAI: oai:DiVA.org:liu-71560DiVA: diva2:450515
Note
Funding Agencies|Ostergotland County Council||Available from: 2011-10-21 Created: 2011-10-21 Last updated: 2017-12-08
In thesis
1. Taurine and Glutathione in cerebrospinal fluid and plasma from patients with psychiatric disorders and healthy controls
Open this publication in new window or tab >>Taurine and Glutathione in cerebrospinal fluid and plasma from patients with psychiatric disorders and healthy controls
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A growing body of results indicate that immunological alterations and oxidative stress are of importance in various mental disorders. The inflammatory changes are possible to detect both in plasma and cerebrospinal fluid (CSF), and different psychiatric disorder exhibit similar changes indicating a common underlying mechanism. The antioxidants are of importance to regulate the redox balance and control the inflammatory processes but the causal relationship between psychiatric disorders and increased oxidative stress is however not fully clarified. Two important antioxidants; taurine and glutathione (GSH), have been suggested to have central nervous system (CNS)-protective properties. They have been found to fluctuate in several mental disorders including schizophrenia and depression but the clinical relevance need further studies.

The general aim of this thesis was to increase the understanding of taurine and the GSH in depression and schizophrenia, two major mental disorders, in comparison to healthy controls.

Correlations between glutathione and taurine levels in blood and CSF were analyzed in healthy male volunteers and we identified a complex pattern of associations showing that the CSF concentration was influenced by body mass index (BMI), age, intraspinal pressure, plasma concentrations the previous day and possible genetic factors. Electroconvulsive therapy (ECT) is used in the treatment of severely depressed patients. In blood collected before the first and after the third ECT, we found a significant decrease in plasma taurine in patients responding to the treatment, while total glutathione was unaltered. In a group of olanzapine treated patients with schizophrenia or schizoaffective disorders, we analysed taurine and glutathione in plasma and CSF and compared with healthy male and female volunteers. We observed increased plasma taurine levels in patients compared with controls, but no difference in CSF taurine and no alteration in glutathione.

This thesis indicates that taurine might play a role in mental disorders such as depression and schizophrenia. Increased knowledge about the complex regulation of taurine and glutathione might provide new insights into the impact of redox balance in the pathophysiology of psychiatric disorder and contribute to a future personalization of the treatment.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2012. 65 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1316
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-84609 (URN)978-91-7519-850-7 (ISBN)
Public defence
2012-11-09, Eken, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Opponent
Supervisors
Available from: 2012-10-15 Created: 2012-10-15 Last updated: 2017-08-30Bibliographically approved

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Samuelsson, MartinVainikka, LindaÖllinger, Karin

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PsychiatryFaculty of Health SciencesDepartment of PsychiatryCell BiologyExperimental PathologyDepartment of Clinical Pathology and Clinical Genetics
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