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A comparison of two methods for estimating refill adherence to statins in Sweden: the RARE project
Nordic School for Public Health.
Nordic School for Public Health.
Medical Prod Agency.
Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Clinical Pharmacology.
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2011 (English)In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 20, no 10, 1073-1079 p.Article in journal (Refereed) Published
Abstract [en]

Purpose To analyse and compare refill adherence to statins estimated with two different methods with a focus on sensitivity to definitions. less thanbrgreater than less thanbrgreater thanMethods Individuals aged 18-85 years who filled a statin prescription for the first time in 1.5 years during 1 January-30 June 2007 were followed until emigration or death or until 2 years after their first statin purchase. The data were collected via linkage between the Swedish Prescribed Drug Register, the National Patient Register and the Total Population Register. Days supply was estimated based on amount dispensed and prescribed dosage. Refill adherence was estimated with the continuous measure of medication acquisition (CMA) and the maximum gap method (cut-off 45days). The impact of altering definitions, for example, regarding hospitalisations, length of observation period and management of overlapping supply, was analysed. less thanbrgreater than less thanbrgreater thanResults The study included 36661 individuals (mean age 64 years, 47% women). The median proportion of days with statins was 95%, and 76% were classified as adherent with a cut-off at andgt;= 80% with CMA. With the maximum gap method, 65% were adherent. Disregarding hospitalisations did not alter the results. Emigration or death at least one year after statin initiation was associated with a lower adherence with both methods, and a shorter observation period and adding overlapping supply to the subsequent prescription increased the adherence estimates. less thanbrgreater than less thanbrgreater thanConclusions The choice of method and definitions, particularly regarding the management of overlapping supplies and the length of observation period, has a substantial impact on estimates of refill adherence to statins.

Place, publisher, year, edition, pages
John Wiley and Sons , 2011. Vol. 20, no 10, 1073-1079 p.
Keyword [en]
medication adherence, drug utilisation, Swedish Prescribed Drug Register, statins
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-71545DOI: 10.1002/pds.2204ISI: 000295261400011OAI: diva2:450539
Available from: 2011-10-21 Created: 2011-10-21 Last updated: 2011-10-21

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PharmacologyFaculty of Health SciencesDepartment of Clinical Pharmacology
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Pharmacoepidemiology and Drug Safety
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