Pain thresholds and pain tolerance during the ovulatory cycle in healthy women: quantitative sensory testing
(English)Manuscript (preprint) (Other academic)
Hormonal influence on pain sensitivity at different menstrual phases is a field of contradictory results. One reason is methodological differences between studies and methodological limitations such as lack of confirmation of cycle phase by measurement of actual hormone levels. In the present study, 14 healthy women were followed during three menstrual cycles and were subjected to a battery of quantitative sensory tests 1-4 after start of menses (follicular phase) and 2-11 days before next menses (luteal phase). The material was analyzed in three different ways: cycle phase determined according to the calendar method; cycle phase determined by hormone values, with cycles showing hormone values outside reference values omitted; and cycles subdivided into three subgroups depending on hormone profile (“normal” cycle; high s-estrogen during the assumed luteal phase; and low progesterone during the assumed luteal phase). However, neither analysis showed any significant differences between the measurement done during immediate after onset of menses and those performed in the period before next menses. Consistent with the results of several previous studies, the findings indicate that pain sensitivity does not seem to vary as a function of the menstrual cycle.
Estrogen, pain, hormonal levels, quantitative sensory testing
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-71868OAI: oai:DiVA.org:liu-71868DiVA: diva2:454818