Influence of estrogen levels on thermal perception, pain thresholds and pain tolerance: Studies on women undergoing in vitro fertilization
2012 (English)In: Journal of Pain, ISSN 1526-5900, E-ISSN 1528-8447, Vol. 13, no 5, 459-466 p.Article in journal (Refereed) Published
We examined the relationship between estrogen and pain in women undergoing in vitro fertilization (IVF). Quantitative sensory tests (QST) were performed twice during the IVF-regimen: once during hormonal down-regulation and once during hormonal upregulation. A group of healthy men and a group of women using monophasic contraceptives were also examined, to control for session-to-session effects. Among the women undergoing IVF, serum 17β-estradiol levels differed strongly between treatments as expected, and increased from 65.7 (SD = 26) pmol/l during the downregulation phase, to 5188 (SD = 2524) pmol/l during the up-regulation phase. Significant outcomes in the QST were only seen for temperature perception thresholds (1.7°C vs. 2.2°C; P = 0.003) and cold pain threshold (11.5°C vs. 14.5°C; P = 0.04). A similar change in cold pain threshold was also seen in the two control groups, however, and statistical analysis suggested that this change was due to a session-to-session effect rather than being the result of hormonal modulation. Heat pain thresholds, heat tolerance, pressure pain thresholds, and the cold pressor test showed no significant differences between sessions. These data demonstrate that pain perception and pain thresholds in healthy women show little, if any, changes even with major variations in serum estradiol levels.
Place, publisher, year, edition, pages
2012. Vol. 13, no 5, 459-466 p.
Estrogen, pain, hormonal levels, quantitative sensory testing
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-71869DOI: 10.1016/j.jpain.2012.01.446ISI: 000304228700005OAI: oai:DiVA.org:liu-71869DiVA: diva2:454826
funding agencies|Swedish Research Council| 7879 |Konung Gustav V:s 80-arsfond||Health Research Council in the South-East of Sweden||Linneus University, Kalmar, Sweden||2011-11-082011-11-082013-01-24Bibliographically approved