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Vascular oxygen content and the tissue oxygenation--a theoretical analysis
Norrland University Hospital.ORCID iD: 0000-0001-8171-2541
Stockholm University and Karolinska Institutet.ORCID iD: 0000-0002-7101-240X
2008 (English)In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 35, no 2, 539-545 p.Article in journal (Refereed) Published
Abstract [en]

Several methods exist for evaluating tumor oxygenation as hypoxia is an important prognostic factor for cancer patients. They use different measuring principles that highlight various aspects of oxygenation. The results could be empirically correlated, but it has been suspected that there could be discordances in some cases. This study describes an analysis of the relationship between vascular and tissue oxygenations. Theoretical simulation has been employed to characterize tissue oxygenations for a broad range of distributions of intervessel distances and vascular oxygenations. The results were evaluated with respect to the implications for practical measurements of tissue oxygenations. The findings showed that although the tissue oxygenation is deterministically related to vascular oxygenation, the relationship between them is not unequivocal. Variability also exists between the fractions of values below the sensitivity thresholds of various measurement methods which in turn could be reflected in the power of correlations between results from different methods or in the selection of patients for prognostic studies. The study has also identified potential difficulties that may be encountered at the quantitative evaluation of the results from oxygenation measurements. These could improve the understanding of oxygenation measurements and the interpretation of comparisons between results from various measurement methods.

Place, publisher, year, edition, pages
2008. Vol. 35, no 2, 539-545 p.
National Category
Cancer and Oncology
URN: urn:nbn:se:liu:diva-71984DOI: 10.1118/1.2830382PubMedID: 18383675OAI: diva2:455886
Available from: 2011-11-11 Created: 2011-11-11 Last updated: 2015-03-03

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Daşu, AlexandruToma-Daşu, Iuliana
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