liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
The effects of hypoxia on the theoretical modelling of tumour control probability
Umeå University.ORCID iD: 0000-0001-8171-2541
Umeå University.ORCID iD: 0000-0002-7101-240X
Umeå University.
2005 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 44, no 6, 563-571 p.Article in journal (Refereed) Published
Abstract [en]

Theoretical modelling of tumour response is increasingly used for the prediction of treatment result and has even been proposed as ranking criteria in some algorithms for treatment planning. Tumour response to radiation is greatly influenced by the details of tumour microenvironment, especially hypoxia, that unfortunately are not always taken into consideration for these simulations. This paper intends to investigate the effects of various assumptions regarding hypoxia distribution in tumours on the predictions of treatment outcome. A previously developed model for simulating theoretically the oxygenation in biologically relevant tissues, including results from oxygen diffusion, consumption and perfusion limitations in tumours, was used to investigate the effects of the different aspects of hypoxia on the predictions of treatment outcome. Thus, both the continuous distribution of values and the temporal variation of hypoxia patterns were taken into consideration and were compared with a 'black-and-white' simplification with a fully hypoxic compartment and a fully oxic one. It was found that the full distribution of oxygenation in the tissue is needed for accurate results. The 'black-and-white' simplification, while showing the same general trends for the predictions of radiation response, could lead to serious over-estimations of the tumour control probability. It was also found that the presence of some hypoxia for every treatment fraction leads to a decrease in the predicted local control, regardless of the change of the hypoxic pattern throughout the duration of the whole treatment. The results thus suggest that the assumptions regarding tumour hypoxia influence very much the predictions of treatment outcome and therefore they have to be very carefully incorporated into the theoretical modelling.

Place, publisher, year, edition, pages
2005. Vol. 44, no 6, 563-571 p.
National Category
Cancer and Oncology
URN: urn:nbn:se:liu:diva-71992DOI: 10.1080/02841860500244435PubMedID: 16165915OAI: diva2:457348
Available from: 2011-11-17 Created: 2011-11-11 Last updated: 2015-03-07

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedOpen Access PDF (140 KB)

Search in DiVA

By author/editor
Daşu, AlexandruToma-Daşu, Iuliana
In the same journal
Acta Oncologica
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link