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Mechanotransduction in cells using polypyrrole microactuators
Linköping University, Department of Science and Technology, Physics and Electronics. (Organic Electronics)ORCID iD: 0000-0002-2071-7768
Karolinska Institutet. (Dept. Neuroscience)
Karolinska Institutet. (Dept. Cell and Molecular Biology)
Karolinska Institutet. (Dept. Neuroscience)
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2011 (English)In: EuroEAP 2011 - First International conference on Electromechanically Active Polymer (EAP) transducers & artificial muscles, 2011Conference paper (Other academic)
Abstract [en]

The effect of mechanical forces on cells is a relatively unexplored area of cell biology. However, mechanical forces play an important role in cell proliferation, function, and stem cell differentiation. For instance in muscle contraction, bone growth, and morphogenesis. There is only a limited selection of tools to study this on a single cell level and/or follow the events in real time. Here, we present novel tools in order to mechanically stimulate (stem) cells both on a single cell level as well as parts of functional monolayers. The devices are designed in order to function with different imaging techniques commonly used in cell biology. The mechanical stimulus is provided by polypyrrole microactuators. These actuators can be operated in salt solutions including cell culture media, making them well suited for cell biology applications. In addition, polypyrrole is known to be biocompatible. We will present devices with which we can stretch cells and show the cellular response to this mechanical stimulation. Since the dawn of eukaryotic cells many parallel molecular mechanisms that respond to mechanical stimuli have evolved. This technology allows us to begin the investigation of these mechanisms on a single cell level.

Place, publisher, year, edition, pages
Keyword [en]
actuator, polypyrrole, mechanotransduction, mechanostimulation
National Category
Cell Biology
URN: urn:nbn:se:liu:diva-72168OAI: diva2:457899
EuroEAP 2011
Available from: 2011-11-21 Created: 2011-11-21 Last updated: 2013-10-07

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Jager, Edwin
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