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Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomas
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology UHL.
1997 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 105, no 9, 730-734 p.Article in journal (Refereed) Published
Abstract [en]

Ki-67 is a protein associated with cell proliferation which is expressed in all phases of the cell cycle except Go. In the present study, Ki-67 expression in 255 human colorectal adenocarcinomas was examined using immunohistochemistry with the monoclonal antibody MIB-1. One hundred and fifty-seven (62%) cases had more than 50% positive tumour cells and 98 (38%) cases less than 50%. The tumours showed a wide range of Ki-67 expression, from 13% to 90%, which indicated a variation in proliferative activity. There was no significant relationship between Ki-67 expression and sex, age, tumour location, Dukes' stage, growth pattern, differentiation, DNA content, S-phase fraction or survival (p > 0.05). In conclusion, the proliferative activity as measured by Ki-67 antibody was not related to clinicopathology and prognosis in colorectal cancer.

Place, publisher, year, edition, pages
Wiley-Blackwell , 1997. Vol. 105, no 9, 730-734 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-72301DOI: 10.1111/j.1699-0463.1997.tb05078.xISI: A1997XZ51500011PubMedID: 9350218OAI: oai:DiVA.org:liu-72301DiVA: diva2:458957
Available from: 2011-11-24 Created: 2011-11-24 Last updated: 2017-12-08

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Jansson, AgnetaSun, Xiao-Feng

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