Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomas
1997 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 105, no 9, 730-734 p.Article in journal (Refereed) Published
Ki-67 is a protein associated with cell proliferation which is expressed in all phases of the cell cycle except Go. In the present study, Ki-67 expression in 255 human colorectal adenocarcinomas was examined using immunohistochemistry with the monoclonal antibody MIB-1. One hundred and fifty-seven (62%) cases had more than 50% positive tumour cells and 98 (38%) cases less than 50%. The tumours showed a wide range of Ki-67 expression, from 13% to 90%, which indicated a variation in proliferative activity. There was no significant relationship between Ki-67 expression and sex, age, tumour location, Dukes' stage, growth pattern, differentiation, DNA content, S-phase fraction or survival (p > 0.05). In conclusion, the proliferative activity as measured by Ki-67 antibody was not related to clinicopathology and prognosis in colorectal cancer.
Place, publisher, year, edition, pages
Wiley-Blackwell , 1997. Vol. 105, no 9, 730-734 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-72301DOI: 10.1111/j.1699-0463.1997.tb05078.xISI: A1997XZ51500011PubMedID: 9350218OAI: oai:DiVA.org:liu-72301DiVA: diva2:458957