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Development of a harmonised method for the profiling of amphetamines: II. Stability of impurities in organic solvents
National Bureau of Investigation, Finland.
Swedish National Laboratory of Forensic Science.
Swedish National Laboratory of Forensic Science.
University of Strathclyde, Glasgow.
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2005 (English)In: Forensic Science International, ISSN 0379-0738, E-ISSN 1872-6283, Vol. 149, no 03-Feb, 231-241 p.Article in journal (Refereed) Published
Abstract [en]

The present study focused on the stability of 22 amphetamine impurities dissolved in six organic solvents: isooctane, toluene, ethanol, dichloromethane, ethyl acetate, and diethyl ether. The aim was to find the most inert, and thereby most suitable, solvent for amphetamine profiling. Mixtures of the impurities were prepared in the different solvents, and changes in the concentrations of the individual compounds over-time were monitored by gas chromatographic analysis after 0, 4, 12, 24, 48, and 96 h. Isooctane and toluene provided the most inert conditions, although, a few of the impurities were insufficiently stable in these two solvents. The present experiments were performed as a part of the development of a harmonised method for profiling of amphetamine. The results can be used to support the choice of organic solvents for sample preparation. They also provide information about the stability of the impurities that are found in profiles of illicit amphetamine. This is essential due to the fact, that unstable compounds can have a negative influence on the comparison of profiles.

Place, publisher, year, edition, pages
Elsevier , 2005. Vol. 149, no 03-Feb, 231-241 p.
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-72285DOI: 10.1016/j.forsciint.2004.06.019ISI: 227862300016OAI: diva2:459037
Available from: 2011-11-24 Created: 2011-11-24 Last updated: 2011-12-02

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Dahlén, Johan
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