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Theoretical simulation of tumour oxygenation--practical applications
Umeå University.ORCID iD: 0000-0001-8171-2541
Umeå University.ORCID iD: 0000-0002-7101-240X
2006 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 578, no 12, 357-362 p.Article in journal (Refereed) Published
Abstract [en]

Theoretical simulation of tissue oxygenation is a robust method that can be used to quantify the tissue oxygenation for a variety of applications. However, it is necessary that the relevant input parameters are used for the model describing the tumour microenvironment. The results of the simulations presented in this article suggest that the accuracy of the simulations depends very much on the method of calculation of the effects of the temporal change of the hypoxic pattern due to the opening and the closure of blood vessels. Thus, the use of average oxygenations might lead to dangerous overestimations of the treatment response. This indicates that care should be taken when incorporating hypoxia information into the biological modelling of tumour response.

Place, publisher, year, edition, pages
2006. Vol. 578, no 12, 357-362 p.
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Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-71989DOI: 10.1007/0-387-29540-2_55PubMedID: 16927716OAI: oai:DiVA.org:liu-71989DiVA: diva2:460782
Available from: 2011-12-01 Created: 2011-11-11 Last updated: 2017-12-08

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Daşu, AlexandruToma-Daşu, Iuliana

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