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Dose prescription and treatment planning based on FMISO-PET hypoxia
Stockholm University and Karolinska Institutet.ORCID iD: 0000-0002-7101-240X
RaySearch Laboratories AB, Stockholm.
Stockholm University and Karolinska Institutet.
Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0001-8171-2541
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2012 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 51, no 2, 222-230 p.Article in journal (Refereed) Published
Abstract [en]

Purpose. The study presents the implementation of a novel method for incorporating hypoxia information from PET-CT imaging into treatment planning and estimates the efficiency of various optimization approaches. Its focuses on the feasibility of optimizing treatment plans based on the non-linear conversion of PET hypoxia images into radiosensitivity maps from the uptake properties of the tracers used.

Material and methods. PET hypoxia images of seven head-and-neck cancer patients were used to determine optimal dose distributions needed to counteract the radiation resistance associated with tumor hypoxia assuming various scenarios regarding the evolution of the hypoxic compartment during the treatment. A research planning system for advanced studies has been used to optimize IMRT plans based on hypoxia information from patient PET images. These resulting plans were compared in terms of target coverage for the same fulfilled constraints regarding the organs at risk.

Results. The results of a planning study indicated the clinical feasibility of the proposed method for treatment planning based on PET hypoxia. Antihypoxic strategies would lead to small improvements in all the patients, but higher effects are expected for the fraction of patients with hypoxic tumors. For these, individualization of the treatment based on hypoxia PET imaging could lead to improved treatment outcome while creating the premises for limiting the irradiation of the surrounding normal tissues.

Conclusions. The proposed approach offers the possibility of improved treatment results as it takes into consideration the heterogeneity and the dynamics of the hypoxic regions. It also provides early identification of the clinical cases that might benefit from dose escalation as well as the cases that could benefit from other counter-hypoxic measures.

Place, publisher, year, edition, pages
Informa Healthcare, 2012. Vol. 51, no 2, 222-230 p.
National Category
Cancer and Oncology
URN: urn:nbn:se:liu:diva-71976DOI: 10.3109/0284186X.2011.599815ISI: 000299385600010PubMedID: 21871003OAI: diva2:460930

funding agencies|Vinnova||EU||Cancer Research Funds of Radiumhemmet||

Available from: 2011-12-01 Created: 2011-11-11 Last updated: 2015-05-07

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Toma-Dasu, IulianaAntonovic, LauraDasu, Alexandru
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