Quantitative analysis of amphetamine in femoral blood from drug-poisoning deaths compared with venous blood from impaired drivers
2011 (English)In: Bioanalysis, ISSN 1757-6180, Vol. 3, no 19, 2195-2204 p.Article in journal (Refereed) Published
Background: Amphetamine is a major drug of abuse worldwide. Here we compare the concentrations of this stimulant amine in femoral blood in drug fatalities with venous blood from impaired drivers. Method: Amphetamine was determined in blood by isotope-dilution GC-MS after liquid-liquid extraction. Results: Amphetamine was the only drug identified in 36 fatalities at mean (median) and highest concentrations of 2.0 mg/l (1.5 mg/l) and 14.0 mg/l. In multiple-drug deaths (n = 383), the concentrations were 0.94 mg/l (0.4 mg/l) and 13.3 mg/l. In impaired drivers with amphetamine as the only drug (n = 6138), the concentrations were 1.0 mg/l (0.8 mg/l) and 11.9 mg/l, compared with 0.78 mg/l (0.6 mg/l) and 22.3 mg/l in multidrug users (n = 8250). Conclusion: Fatal amphetamine poisonings cannot be identified on the basis of the concentration in blood alone, owing to the development of tolerance and the toxicity of co-ingested substances.
Place, publisher, year, edition, pages
Future Science , 2011. Vol. 3, no 19, 2195-2204 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-72663DOI: 10.4155/BIO.11.222ISI: 000296920300010OAI: oai:DiVA.org:liu-72663DiVA: diva2:461126