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Quantitative analysis of amphetamine in femoral blood from drug-poisoning deaths compared with venous blood from impaired drivers
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Drug Research.
National Board for Forensic Medicine.
Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
2011 (English)In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 3, no 19, 2195-2204 p.Article in journal (Refereed) Published
Abstract [en]

Background: Amphetamine is a major drug of abuse worldwide. Here we compare the concentrations of this stimulant amine in femoral blood in drug fatalities with venous blood from impaired drivers. Method: Amphetamine was determined in blood by isotope-dilution GC-MS after liquid-liquid extraction. Results: Amphetamine was the only drug identified in 36 fatalities at mean (median) and highest concentrations of 2.0 mg/l (1.5 mg/l) and 14.0 mg/l. In multiple-drug deaths (n = 383), the concentrations were 0.94 mg/l (0.4 mg/l) and 13.3 mg/l. In impaired drivers with amphetamine as the only drug (n = 6138), the concentrations were 1.0 mg/l (0.8 mg/l) and 11.9 mg/l, compared with 0.78 mg/l (0.6 mg/l) and 22.3 mg/l in multidrug users (n = 8250). Conclusion: Fatal amphetamine poisonings cannot be identified on the basis of the concentration in blood alone, owing to the development of tolerance and the toxicity of co-ingested substances.

Place, publisher, year, edition, pages
Future Science , 2011. Vol. 3, no 19, 2195-2204 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-72663DOI: 10.4155/BIO.11.222ISI: 000296920300010OAI: oai:DiVA.org:liu-72663DiVA: diva2:461126
Available from: 2011-12-02 Created: 2011-12-02 Last updated: 2017-12-08

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Jones, A WayneAhlner, Johan

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