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Accumulation and activation of natural killer cells in local intraperitoneal HIV-1/MuLV infection results in early control of virus infected cells
Karolinska Institutet.
Karolinska Institutet.
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
Karolinska Institutet.
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2011 (English)In: Cellular Immunology, ISSN 0008-8749, E-ISSN 1090-2163, Vol. 272, no 1, 71-78 p.Article in journal (Refereed) Published
Abstract [en]

Natural killer (NK) cells are important effectors in resistance to viral infections. The role of NK cells in the acute response to human immunodeficiency virus 1 (HIV-1) infected cells was investigated in a mouse model based on a HIV-1/murine leukemia virus (MuLV) pseudovirus. Splenocytes infected with HIV-1/MuLV were injected intraperitoneally and local immunologic responses and persistence of infected cells were investigated. In vivo depletion with an anti-NK1.1 antibody showed that NK cells are important in resistance to virus infected cells. Moreover, NK cell frequency in the peritoneal cavity increased in response to infected cells and these NK cells had a more mature phenotype, as determined by CD27 and Mac-1 expression. Interestingly, after injection of HIV-1/MuLV infected cells, but not MuLV infected cells, peritoneal NK cells had an increased cytotoxic activity.

Place, publisher, year, edition, pages
2011. Vol. 272, no 1, 71-78 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-72689DOI: 10.1016/j.cellimm.2011.09.005OAI: diva2:461495
Available from: 2011-12-04 Created: 2011-12-04 Last updated: 2011-12-09

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Hinkula, Jorma
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