The role of residence near hazardous waste sites containing benzene in the development of hematologic cancers in upstate New York
2011 (English)In: INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH, ISSN 1232-1087, Vol. 24, no 4, 327-338 p.Article in journal (Refereed) Published
Epidemiologic studies suggest an association between environmental exposure to benzene and hematologic cancers, but the relationship is not firmly established. The aim of this study was to assess the potential association between residence near hazardous waste sites containing benzene and hospitalization discharge rates for persons having hematologic cancers. less thanbrgreater than less thanbrgreater thanWe determined the number of hospital discharges of people with hematologic cancers in New York State except for New York City for the years 1993 to 2008.Descriptive statistics and negative binomial regression models were used to compare the rates of hospitalization of residents in zip codes containing hazardous waste sites containing benzene to the rates of discharges from residents in zip codes without waste sites. less thanbrgreater than less thanbrgreater thanWhen adjusting for potential confounders we found a 15% increase in the rate of hospitalization for chronic lymphatic leukemia (CLL) [rate ratio (RR): 1.15; 95% confidence interval (CI): 1.00-1.33], a 22% increase in the rate of discharges for total leukemia (RR: 1.22; 95% CI: 1.04-1.43) and a 17% increase in the rate of discharges for total lymphoma (RR: 1.17; 95% CI: 1.02-1.35) in the benzene exposed sites. We found greater effects of exposure in African Americans compared to Caucasians, females compared to males and people with higher socioeconomic status (SES) compared to those with lower SES for several of the diseases studied. less thanbrgreater than less thanbrgreater thanAfter controlling for major confounders we found statistically significant increases in discharge rates for several hematologic cancers in persons residing in zip codes containing benzene waste sites. These results provide additional support for a relationship between environmental exposure to benzene and risk of hematologic cancers.
Place, publisher, year, edition, pages
Nofer Institute of Occupational Medicine , 2011. Vol. 24, no 4, 327-338 p.
Environmental exposure, Lymphoma, Leukemia, Ecological study, Ethnic difference
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-72825DOI: 10.2478/s13382-011-0037-8ISI: 000297167900002OAI: oai:DiVA.org:liu-72825DiVA: diva2:462806
Funding Agencies|Institute for Health and the Environment, University at Albany, Rensselaer, New York, USA||Linkoping University Medical School||2011-12-082011-12-082011-12-15