Susceptibility to winter vomiting disease: a sweet matter
2011 (English)In: Reviews in Medical Virology, ISSN 1052-9276, E-ISSN 1099-1654, Vol. 21, no 6, 370-382 p.Article, review/survey (Refereed) Published
Norovirus, the cause of winter vomiting disease, has emerged in recent years to be a major cause of sporadic and epidemic gastroenteritis worldwide. The virus has been estimated to cause andgt;200 000 deaths each year in developing countries. Although the virus is highly contagious, volunteer and field studies have shown that a subset of individuals appears resistant to infections. A single nucleotide mutation (G428A) in the fucosyltransferase gene (FUT2) on chromosome 19 provides strong protection from infection in 20% of the white population. Histo-blood group ABO(H) antigens with terminal fucose are believed to function as receptors for human norovirus in the gastrointestinal tract, but also negatively charged potential receptors have been identified. Norovirus infection is a unique example where a single nucleotide mutation in a fucosyltransferase gene plays a crucial role in susceptibility to one of the most common viral diseases. This review discusses the role of host genetics and carbohydrate structures in susceptibility to winter vomiting disease.
Place, publisher, year, edition, pages
John Wiley and Sons , 2011. Vol. 21, no 6, 370-382 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-72820DOI: 10.1002/rmv.704ISI: 000296904500005OAI: oai:DiVA.org:liu-72820DiVA: diva2:462833
Funding Agencies|Swedish Research Council|1039282662010-878|2011-12-082011-12-082011-12-08