Change in testosterone concentrations over time is a better predictor than the actual concentrations for symptoms of late onset hypogonadism
2011 (English)In: The Aging Male, ISSN 1368-5538, E-ISSN 1473-0790, Vol. 14, no 4, 249-256 p.Article in journal (Refereed) Published
Background. Symptoms of late-onset hypogonadism (LOH) and concentrations of testosterone (T) and bioavailable testosterone (BT) were studied in relation to the data from the same men 5 years earlier. less thanbrgreater than less thanbrgreater thanMethods. In 2008, 282 men, aged 60-82 years, answered a questionnaire regarding demographic data, medical history, different symptoms of LOH and the 10 questions from the Androgen Decline in Aging Males (ADAM)-questionnaire. Blood samples were analysed for concentrations of T and calculations were made for BT. less thanbrgreater than less thanbrgreater thanResults. A total of 87.2% of the questionnaires were returned and analysed, and 75.2% of the responders gave blood samples. The oldest third of the men were most affected by LOH symptoms (p andlt; 0.05). Both T and BT concentrations decreased during the 5 years (p andlt; 0.05) but only the symptom less strong erections changed significantly (p andlt; 0.05). Men reporting one of the four specific symptoms from the ADAM-questionnaire for the first time in 2008 had a higher loss of T and BT than men who had unchanged or fewer symptoms than that reported in 2003. less thanbrgreater than less thanbrgreater thanConclusions. The magnitude of the decrease in concentrations is a better predictor of LOH than are the actual concentrations of T and BT. A combination of symptoms predicts LOH better than any single symptom.
Place, publisher, year, edition, pages
Informa Healthcare , 2011. Vol. 14, no 4, 249-256 p.
Men, andrology, climacteric, questionnaires, testosterone, androgens
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-72806DOI: 10.3109/13685538.2011.582527ISI: 000296795000006OAI: oai:DiVA.org:liu-72806DiVA: diva2:463287
Funding Agencies|Swedish Medical Research Council|K2000-72X-12651-04B|2011-12-092011-12-082011-12-15