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Change in testosterone concentrations over time is a better predictor than the actual concentrations for symptoms of late onset hypogonadism
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Occupational and Environmental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Clinical Chemistry.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
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2011 (English)In: The Aging Male, ISSN 1368-5538, E-ISSN 1473-0790, Vol. 14, no 4, 249-256 p.Article in journal (Refereed) Published
Abstract [en]

Background. Symptoms of late-onset hypogonadism (LOH) and concentrations of testosterone (T) and bioavailable testosterone (BT) were studied in relation to the data from the same men 5 years earlier. less thanbrgreater than less thanbrgreater thanMethods. In 2008, 282 men, aged 60-82 years, answered a questionnaire regarding demographic data, medical history, different symptoms of LOH and the 10 questions from the Androgen Decline in Aging Males (ADAM)-questionnaire. Blood samples were analysed for concentrations of T and calculations were made for BT. less thanbrgreater than less thanbrgreater thanResults. A total of 87.2% of the questionnaires were returned and analysed, and 75.2% of the responders gave blood samples. The oldest third of the men were most affected by LOH symptoms (p andlt; 0.05). Both T and BT concentrations decreased during the 5 years (p andlt; 0.05) but only the symptom less strong erections changed significantly (p andlt; 0.05). Men reporting one of the four specific symptoms from the ADAM-questionnaire for the first time in 2008 had a higher loss of T and BT than men who had unchanged or fewer symptoms than that reported in 2003. less thanbrgreater than less thanbrgreater thanConclusions. The magnitude of the decrease in concentrations is a better predictor of LOH than are the actual concentrations of T and BT. A combination of symptoms predicts LOH better than any single symptom.

Place, publisher, year, edition, pages
Informa Healthcare , 2011. Vol. 14, no 4, 249-256 p.
Keyword [en]
Men, andrology, climacteric, questionnaires, testosterone, androgens
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-72806DOI: 10.3109/13685538.2011.582527ISI: 000296795000006OAI: oai:DiVA.org:liu-72806DiVA: diva2:463287
Note
Funding Agencies|Swedish Medical Research Council|K2000-72X-12651-04B|Available from: 2011-12-09 Created: 2011-12-08 Last updated: 2017-12-08

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Spetz, Anna-ClaraFredrikson, MatsTheodorsson, ElvarHammar, Mats

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Obstetrics and gynecologyFaculty of Health SciencesDepartment of Gynecology and Obstetrics in LinköpingOccupational and Environmental MedicineClinical ChemistryDepartment of Clinical Chemistry
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