Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer
2011 (English)In: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 26, no 12, 1519-1524 p.Article in journal (Refereed) Published
Purpose The aim of this study was to evaluate the prevalence and clinical significance of caspase-10 mRNA expression in stage II colorectal cancer. less thanbrgreater than less thanbrgreater thanMethods Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to analyze caspase-10 expression in cancer tissue and corresponding normal mucosa from 120 patients with stage II colorectal cancer. Variables were analyzed by Chi-square test or Fishers exact test. Survival was evaluated with method of Kaplan-Meier. Multivariate analysis was performed with Coxs proportional hazards model. less thanbrgreater than less thanbrgreater thanResults The expression of caspase-10 mRNA was found to be downregulated in cancer tissue compared to normal mucosa (P = 0.001). Poorly differentiated cancer showed lower mRNA expression than cancer with greater differentiation (P = 0.031). Univariate survival curves, estimated using the method of Kaplan-Meier, defined a significant association between caspase-10 expression and both overall survival (P = 0.012) and disease-free survival (P = 0.021). A multivariate analysis, performed by Coxs proportional hazards regression model, confirmed that a low caspase-10 expression was the only significant factor to predict poor prognosis in patients with stage II colorectal cancer. less thanbrgreater than less thanbrgreater thanConclusion Our data indicate that caspase-10 expression, measured by quantitative real-time RT-PCR, is a possible prognostic factor in patients with stage II colorectal cancer.
Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2011. Vol. 26, no 12, 1519-1524 p.
Apoptosis, Caspase-10, Colorectal cancer, Stage II, Survival
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-73099DOI: 10.1007/s00384-011-1239-zISI: 000297246100003OAI: oai:DiVA.org:liu-73099DiVA: diva2:466456
Funding Agencies|National Natural Science Founding of China|30801331|2011-12-162011-12-162011-12-16