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Pegylated liposomal doxorubicin as first-line monotherapy in elderly women with locally advanced or metastatic breast cancer: Novel treatment predictive factors identified
Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology UHL.
Central Hospital, Karlstad.
Karolinska University Hospital, Stockholm.
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2011 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 313, no 2, 145-153 p.Article in journal (Refereed) Published
Abstract [en]

We investigated the efficacy and safety of single-agent pegylated liposomal doxorubicin (PLD) as first-line treatment for elderly women with advanced breast cancer and evaluated predictive markers for response and toxicity. Twenty-five women ⩾65years received 40mg/m(2) PLD every 28days. Time to treatment failure (TTF), response rate, time to progression (TTP) and overall survival (OS) was calculated. The ABCB1 single nucleotide polymorphisms (SNP), tumor MRN complex, and TOPOIIα were analyzed. A mean of 7.4 cycles PLD were administered and TTF was 5.5months and OS 20.6months. ABCB1 SNPs were found to correlate to both efficacy and toxicity, while tumor expression of the MRN complex and TOPOIIα correlated to TTP. PLD is a safe and effective treatment for elderly breast cancer patients. Also potential predictive markers were identified.

Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 313, no 2, 145-153 p.
Keyword [en]
Anthracycline, Elderly, Genotype, Metastatic breast cancer, MRN complex, Topoisomerase IIa
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-73049DOI: 10.1016/j.canlet.2011.07.017ISI: 000297895800004PubMedID: 22056077OAI: diva2:467896
Available from: 2011-12-20 Created: 2011-12-14 Last updated: 2013-03-12

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Green, HenrikStål, OlleMalmström, Annika
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Clinical PharmacologyFaculty of Health SciencesOncologyDepartment of Oncology UHLCell BiologyLAH Linköping
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