Pegylated liposomal doxorubicin as first-line monotherapy in elderly women with locally advanced or metastatic breast cancer: Novel treatment predictive factors identified
2011 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 313, no 2, 145-153 p.Article in journal (Refereed) Published
We investigated the efficacy and safety of single-agent pegylated liposomal doxorubicin (PLD) as first-line treatment for elderly women with advanced breast cancer and evaluated predictive markers for response and toxicity. Twenty-five women ⩾65years received 40mg/m(2) PLD every 28days. Time to treatment failure (TTF), response rate, time to progression (TTP) and overall survival (OS) was calculated. The ABCB1 single nucleotide polymorphisms (SNP), tumor MRN complex, and TOPOIIα were analyzed. A mean of 7.4 cycles PLD were administered and TTF was 5.5months and OS 20.6months. ABCB1 SNPs were found to correlate to both efficacy and toxicity, while tumor expression of the MRN complex and TOPOIIα correlated to TTP. PLD is a safe and effective treatment for elderly breast cancer patients. Also potential predictive markers were identified.
Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 313, no 2, 145-153 p.
Anthracycline, Elderly, Genotype, Metastatic breast cancer, MRN complex, Topoisomerase IIa
National CategoryClinical Medicine
IdentifiersURN: urn:nbn:se:liu:diva-73049DOI: 10.1016/j.canlet.2011.07.017ISI: 000297895800004PubMedID: 22056077OAI: oai:DiVA.org:liu-73049DiVA: diva2:467896