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Large Eddy Simulation of Stenotic Flow for Wall Shear Stress Estimation - Validation and Application
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, The Institute of Technology.
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, The Institute of Technology.ORCID iD: 0000-0003-1942-7699
FS Dynamics Sweden AB, Gothenburg.
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, The Institute of Technology.ORCID iD: 0000-0001-5526-2399
2011 (English)In: WSEAS Transactions on Biology and Biomedicine, ISSN 1109-9518, Vol. 8, no 3, 86-101 p.Article in journal (Refereed) Published
Abstract [en]

Turbulent flow in the cardiovascular system may increase the risk for severe arterial disease. This workaddresses the feasibility of Large Eddy Simulation (LES) using a general purpose code as a tool for assessmentof cardiovascular flow and investigates Wall Shear Stress (WSS) in steady as well as pulsating turbulent pipeflow. Poiseuille flow was specified at the inlet, and with a suitable ammount of perturbations at the inlet it waspossible to predict experimental data. The extent of the recirculation zone was affected by the inlet disturbances,and magnitude as well as direction of the WSS vector varied significantly at the reattachment point. For thepulsating flow, WSS shows a complex pattern with different spatial and temporal variation along the pipe. Thewall shear stress gradient was calculated on the entire post-stenotic surface and each component in the gradientwas investigated. The off-diagonal components in the gradient are usually assumed to be small, but here they werefound to be on the same order of magnitude as the diagonal terms. This work demonstrates the need for a scaleresolving simulation technique to accurately model cardiovascular flows.

Place, publisher, year, edition, pages
2011. Vol. 8, no 3, 86-101 p.
Keyword [en]
Turbulence, Large Eddy Simulation, Cardiovascular Flow, Wall Shear Stress
National Category
Fluid Mechanics and Acoustics
Identifiers
URN: urn:nbn:se:liu:diva-73211OAI: oai:DiVA.org:liu-73211DiVA: diva2:469105
Available from: 2011-12-22 Created: 2011-12-22 Last updated: 2016-03-14
In thesis
1. Turbulent Flow in Constricted Blood Vessels: Quantification of Wall Shear Stress Using Large Eddy Simulation
Open this publication in new window or tab >>Turbulent Flow in Constricted Blood Vessels: Quantification of Wall Shear Stress Using Large Eddy Simulation
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The genesis of atherosclerosis has previously been shown to be affected by the frictional load from the blood on the vessel wall, called the wall shear stress (WSS). Assessment of WSS can therefore provide important information for diagnoses, intervention planning, and follow‐up. Calculation of WSS requires high‐resolved velocity data from the vessel, which in turn can be obtained using computational fluid dynamics (CFD). In this work large eddy simulation LES was successfully used to simulate transitional flow in idealized as well as subject specific vessel models. It was shown that a scale resolving technique is to prefer for this application, since much valuable information otherwise is lost. Besides, Reynolds‐Averaged Navier‐Stokes (RANS) models have generally failed to predict this type of flow.

Non‐pulsating flows of Reynolds numbers up to 2 000 in a circular constricted pipe showed that turbulence is likely to occur in the post‐stenotic region, which resulted in a complex WSS pattern characterized by large spatial as well temporal fluctuations in all directions along the wall. Time averaged streamwise WSS was relatively high, while time averaged circumferential WSS was low, meaning that endothelial cells in that region would be exposed to oscillations in a stretched state in the streamwise direction and in a relaxed state in the circumferential direction.

Since every vessel is unique, so is also its WSS pattern. Hence the CFD simulations must be done in subject specific vessel models. Such can be created from anatomical information acquired with magnetic resonance imaging (MRI). MRI can also be used to obtain velocity boundary conditions for the simulation. This technique was used to investigate pulsating flow in a subject specific normal human aorta. It was shown that even the flow in healthy vessels can be very disturbed and turbulence like, and even for this case large WSS variations were seen. It was also shown that regions around branches from the aorta, known to be susceptible for atherosclerosis, were characterized by high time averaged WSS and high oscillatory shear index.

Finally, the predictive capability of CFD was investigated. An idealized model of a human aorta with a coarctation and post‐stenotic dilatation was studied before and after a possible repair of the constriction. The results suggested that small remaining abnormalities in the geometry may deteriorate the chances for a successful treatment. Also, high values of shear rate and Reynolds stresses were found in the dilatation after the constriction, which previous works have shown means increased risk for thrombus formation and hemolysis.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2013. 57 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1558
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-100918 (URN)10.3384/diss.diva-100918 (DOI)978-91-7519-473-8 (ISBN)
Public defence
2013-12-10, C3, hus C, Campus Valla, Linköpings universitet, Linköping, 10:15 (English)
Opponent
Supervisors
Available from: 2013-11-14 Created: 2013-11-14 Last updated: 2017-03-27Bibliographically approved

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Gårdhagen, RolandLantz, JonasKarlsson, Matts

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