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Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 Cotreatment versus Insulin-Like Growth Factor-I Alone in Two Brothers with Growth Hormone Insensitivity Syndrome: Effects on Insulin Sensitivity, Body Composition and Linear Growth
Karolinska Hospital and Institute.
Karolinska Hospital and Institute.
Karolinska Hospital and Institute.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Pediatrics.
2011 (English)In: HORMONE RESEARCH IN PAEDIATRICS, ISSN 1663-2818, Vol. 76, no 5, 355-366 p.Article in journal (Refereed) Published
Abstract [en]

Background/Aims: Growth hormone insensitivity syndrome (GHIS) is caused by a defective growth hormone receptor (GHR) and is associated with insulin-like growth factor-I (IGF-I) deficiency, severely short stature and, from adolescence, fasting hyperglycemia and obesity. We studied the effects of treatment with IGF-I in either a 1:1 molar complex with IGFBP-3 (IGF-I/BP-3-Tx) or with IGF-I alone (IGF-I-Tx) on metabolism and linear growth. Methods: Two brothers, compound heterozygous for a GHR gene defect, were studied. After 8 months without treatment, we examined the short- and long-term effects of IGF-I/BP-3-Tx and, subsequently, IGF-I-Tx on 12-hour overnight levels of IGF-I, GH, insulin, IGFBP-1, insulin sensitivity by hyperinsulinemic euglycemic clamp, body composition by dual-energy X-ray absorptiometry and linear growth. Results: Mean overnight levels of insulin decreased and IGFBP-1, a measure of hepatic insulin sensitivity, increased on both regimens, but was more pronounced on IGF-I-Tx. Insulin sensitivity by clamp showed no consistent changes. Lean body mass increased and abdominal fat mass decreased in both subjects on IGF-I-Tx. However, the changes were inconsistent during IGF-I/BP-3-Tx. Height velocity was low without treatment, increased slightly on IGF-I/BP-3-Tx and doubled on IGF-I-Tx. Conclusion: Both modalities of IGF-I improved determinants of hepatic insulin sensitivity, body composition and linear growth rate; however, IGF-I alone seemed to be more efficient. 

Place, publisher, year, edition, pages
Karger , 2011. Vol. 76, no 5, 355-366 p.
Keyword [en]
Growth hormone insensitivity syndrome; Insulin-like growth factor-I; Body composition; Growth; Children
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-73360DOI: 10.1159/000330410ISI: 000297576800010OAI: oai:DiVA.org:liu-73360DiVA: diva2:471329
Available from: 2012-01-02 Created: 2012-01-02 Last updated: 2017-02-24

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Bang, Peter

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  • apa
  • harvard1
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