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Precise Neurotransmitter-Mediated Communication with Neurons In Vitro and In Vivo Using Organic Electronics
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-2799-3490
Karolinska Institutet.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.ORCID iD: 0000-0001-5154-0291
Karolinska Institutet.
2010 (English)In: Journal of Biomechanical Science and Engineering, ISSN 1880-9863, Vol. 5, no 3, 208-217 p.Article in journal (Refereed) Published
Abstract [en]

Attempts to interface human-made systems with neural systems are commonly based on direct electrical stimulation or exogenous drug delivery. Few techniques have attempted to mimic neurons' own combination of electronic and chemical signaling with endogenous substances. We demonstrate below the organic electronic ion pump (OEIP), a technology which aims to accomplish just that: electronically controlled delivery of ions, neurotransmitters and other bio-substances. Based on electrophoretic migration through an organic electronic system, delivery is diffusive and non-convective, that is, without fluid flow. Various experiments involving OEIP technology are reviewed, culminating in its use, in an encapsulated form, to modulate sensory function in a living animal. As a first step towards an “artificial neuron”, this technology has significant potential for both neural system interfacing and in the treatment of various neurological disorders.

Place, publisher, year, edition, pages
The Japan Society of Mechanical Engineers , 2010. Vol. 5, no 3, 208-217 p.
Keyword [en]
Organic Electronics, Drug Delivery, Neurotransmitters, Electrophoresis, In Vivo
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-73404DOI: 10.1299/jbse.5.208OAI: oai:DiVA.org:liu-73404DiVA: diva2:471808
Available from: 2012-01-03 Created: 2012-01-03 Last updated: 2017-02-03

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Simon, DanielBERGGREN, Magnus

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