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Tumoricidal Effects of Nanomaterials in HeLa Cell Line
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Pakistan Institute for Engineering and Applied Science.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
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2011 (English)In: Laser physics, ISSN 1054-660X, E-ISSN 1555-6611, Vol. 21, no 11, 1978-1988 p.Article in journal (Refereed) Published
Abstract [en]

The current study exhibits the cellular response of HeLa (cervical cancer) cells to metal oxides ultrafine nanomaterials e.g. manganese dioxide nanowires (MnO(2) NRs), iron oxide nanoparticles (Fe(2)O(3) NPs) and zinc oxide nanorods (ZnO NRs) as bare and as conjugated with photosensitizers. For cytotoxic evaluations, the cellular morphology, (MTT) assay, reactive oxygen species (ROS) production were used for cases with and without photo sensitizer as well illuminated with UV-visible laser exposed conditions. Three different photosensitizers were tested. These are 5-aminolevulinic acid (5-ALA), Photofrin (R), and protoporphyrin dimethyl ester (PPDME). Significant loss in cell viability was noted with 100-500 mu g/ml in bare and conjugated forms of the metal oxides used. The effect was insignificant with lower concentrations (0.05-50 mu g/ml). While notable anticancer effect of 5-ALA under 30 J/cm(2) of diode laser irradiation was noted as compared to other photo sensitizer. By increasing the UV irradiation time of labeled cells, generation of ROS was observed, indicating the possibility of achieving efficient photodynamic therapy (PDT).

Place, publisher, year, edition, pages
MAIK Nauka/Interperiodica , 2011. Vol. 21, no 11, 1978-1988 p.
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Engineering and Technology
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URN: urn:nbn:se:liu:diva-73340DOI: 10.1134/S1054660X1119011XISI: 000297732800026OAI: oai:DiVA.org:liu-73340DiVA: diva2:471848
Available from: 2012-01-03 Created: 2012-01-02 Last updated: 2017-12-08

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Nur, OmerWillander, Magnus

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