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Quantification of indoxyl sulphate in the spent dialysate using fluorescence spectra
Tallinn University.
Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Nephrology UHL.
Tallinn University.
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2011 (English)In: IFMBE Proceedings, ISSN 1680-0737, Vol. 34, 45-48 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate the possibility to determine the amount of Indoxyl Sulphate (IS) in the spent dialysate using fluorescence spectra. Eight uremic patients from Linköping were studied during their three dialysis treatments in one week at the Department of Dialysis and Nephrology at Linköping University Hospital. Dialysate samples were taken during each treatment and analyzed, IS concentration was estimated using HPLC method, and fluorescence spectra was measured with spectrofluorophotometer. The fluorescence spectral values were transformed into IS concentration using regression model from total material noted as fluorescence method (F). Achieved results were compared regarding mean values and SD. Mean value of IS estimated by HPLC was 1.21±0.77 mg/l and by F 1.22±0.72 mg/l. Concentrations were not significantly different (p≤0,05). This study indicates, that it is possible to estimate the concentration of IS using only fluorescence values of the spent dialysate.

Place, publisher, year, edition, pages
2011. Vol. 34, 45-48 p.
Keyword [en]
Indoxyl Sulphate – dialysis – fluorescence – spectra – uremic toxins
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-73440DOI: 10.1007/978-3-642-21683-1_11OAI: diva2:472459
15th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC 2011) Available from: 2012-01-03 Created: 2012-01-03 Last updated: 2012-01-11

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Uhlin, Fredrik
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Internal MedicineFaculty of Health SciencesDepartment of Nephrology UHL
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