Cell Interaction Study of Amyloid by Using Luminescent Conjugated Polythiophene: Implication that Amyloid Cytotoxicity Is Correlated withProlonged Cellular Binding
2012 (English)In: ChemBioChem (Print), ISSN 1439-4227, E-ISSN 1439-7633, Vol. 13, no 3, 358-363 p.Article in journal (Refereed) Published
Needles and noodles: Studying amyloid toxicity is important for understanding protein misfolding diseases. Using a luminescent conjugated polythiophene, we found that cell binding of nontoxic filamentous amyloids of insulin and β2-microglobulin was less efficient than that of toxic fibrillar amyloids; this suggests a correlation between amyloid toxicity and cell binding.
Place, publisher, year, edition, pages
Weinheim, Germany: Wiley-VCH Verlagsgesellschaft, 2012. Vol. 13, no 3, 358-363 p.
amyloid beta-peptides; cell binding; cytotoxicity; luminescent conjugated polythiophene (LCP); protein folding
Cell and Molecular Biology
IdentifiersURN: urn:nbn:se:liu:diva-73501DOI: 10.1002/cbic.201100467ISI: 000299834900005OAI: oai:DiVA.org:liu-73501DiVA: diva2:473228