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Right-hemispheric cortical contributions to language ability in healthy adults
Linköping University, Center for Medical Image Science and Visualization, CMIV. Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-3587-3568
Linköping University, Center for Medical Image Science and Visualization, CMIV. Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics UHL.
Linköping University, Department of Clinical and Experimental Medicine, Speech and Language Pathology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-2208-0630
Linköping University, Center for Medical Image Science and Visualization, CMIV. Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics UHL. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0001-8661-2232
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2012 (English)In: Brain and Language, ISSN 0093-934X, E-ISSN 1090-2155, Vol. 120, no 3, 395-400 p.Article in journal (Refereed) Published
Abstract [en]

In this study we investigated the correlation between individual linguistic ability based on performance levels and their engagement of typical and atypical language areas in the brain. Eighteen healthy subjects between 21 and 64 years participated in language ability tests, and subsequent functional MRI scans measuring brain activity in response to a sentence completion and a word fluency task. Performance in both reading and high-level language tests correlated positively with increased right-hemispheric activation in the inferior frontal gyrus (specifically Brodmann area 47), the dorsolateral prefrontal cortex (DLPFC), and the medial temporal gyrus (Brodmann area 21). In contrast, we found a negative correlation between performance and left-hemispheric DLPFC activation.

Our findings indicate that the right lateral frontal and right temporal regions positively modulate aspects of language ability.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 120, no 3, 395-400 p.
Keyword [en]
Linguistics; Functional Magnetic Resonance Imaging; Functional laterality; Task performance; Reading; Fluency
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-73623DOI: 10.1016/j.bandl.2011.10.002ISI: 000301759100019PubMedID: 22115846OAI: oai:DiVA.org:liu-73623DiVA: diva2:475258
Note
funding agencies|Stahls Foundation||Strategic Research Area of the Center of Medical Image Science and Visualization (CMIV) at Linkoping University, Sweden||Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2017-12-08
In thesis
1. Mind your Language, All Right? Performance-dependent neural patterns of language
Open this publication in new window or tab >>Mind your Language, All Right? Performance-dependent neural patterns of language
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The main aim of this dissertation was to investigate the difference in neural language patternsrelated to language ability in healthy adults. The focus lies on unraveling the contributions of theright‐hemispheric homologues to Broca’s area in the inferior frontal gyrus (IFG) and Wernicke’s areain the posterior temporal and inferior parietal lobes. The functions of these regions are far from fullyunderstood at present. Two study populations consisting of healthy adults and a small group ofpeople with generalized epilepsy were investigated. Individual performance scores in tests oflanguage ability were correlated with brain activation obtained with functional magnetic resonanceimaging during semantic and word fluency tasks. Performance‐dependent differences were expectedin the left‐hemispheric Broca’s and Wernicke’s area and in their right‐hemispheric counterparts.

PAPER I revealed a shift in laterality towards right‐hemispheric IFG and posterior temporal lobeactivation, related to high semantic performance. The whole‐brain analysis results of PAPER IIrevealed numerous candidate regions for language ability modulation. PAPER II also confirmed thefinding of PAPER I, by showing several performance‐dependent regions in the right‐hemispheric IFGand the posterior temporal lobe.

In PAPER III, a new study population of healthy adults was tested.Again, the right posterior temporal lobe was related to high semantic performance. A decrease in lefthemisphericIFG activation could be linked to high word fluency ability. In addition, task difficultywas modulated. Increased task complexity showed to correlate positively with bilateral IFGactivation.

Lastly, PAPER IV investigated anti‐correlated regions. These regions are commonly knownas the default mode network (DMN) and are normally suppressed during cognitive tasks. It wasfound that people with generalized epilepsy had an inadequate suppression of regions in the DMN,and showed poorer performance in a complex language test. The results point to neural adaptabilityin the IFG and temporal lobe. Decreased left‐lateralization of the IFG and increased rightlateralizationof the posterior temporal lobe are proposed as characteristics of individuals with highlanguage ability.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2013. 56 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1358
Keyword
Language ability, performance, fMRI, functional magnetic resonance imaging, Broca, Wernicke, temporal lobe, inferior frontal gyrus, reading, fluency, lateralization, lateralisation, right hemisphere, performance-dependent, neural activation
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-91053 (URN)978-91-7519-668-8 (ISBN)
Public defence
2013-05-17, Berzeliussalen, Campus US, Linköpings universitet, Linköping, 13:15 (English)
Opponent
Supervisors
Available from: 2013-04-16 Created: 2013-04-12 Last updated: 2014-10-02Bibliographically approved

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van Ettinger-Veenstra, HeleneRagnehed, MattiasMcAllister, AnitaLundberg, PeterEngström, Maria

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van Ettinger-Veenstra, HeleneRagnehed, MattiasMcAllister, AnitaLundberg, PeterEngström, Maria
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Center for Medical Image Science and Visualization, CMIVRadiologyFaculty of Health SciencesDepartment of Radiation Physics UHLSpeech and Language PathologyRadiation PhysicsDepartment of Radiology in Linköping
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