Overexpression of GLUT1 in colorectal cancer is independently associated with poor prognosis
2011 (English)In: International Journal of Biological Markers, ISSN 0393-6155, Vol. 26, no 3, 166-172 p.Article in journal (Refereed) Published
Background: To investigate the expression of glucose transporter 1 (GLUT1) in colorectal cancer (CRC) and its relationship to clinicopathological variables. Methods: The expression of GLUT1 in 163 primary tumors together with the corresponding normal mucosa, and 36 liver metastases was examined using real-time PCR. Results: The mean value of GLUT1 was higher in primary tumors (50.390 +/- 68.648) than in the corresponding normal mucosa (20.437 +/- 28.703, p less than 0.0001), while there was no significant difference in GLUT1 expression between CRC and liver metastasis (50.390 +/- 68.648 vs 52.277 +/- 52.482, p = 0.190). In CRCs, GLUT1 expression was higher in poorly differentiated than in well and moderately differentiated tumors (p = 0.022), and higher in stage III + IV than in stage I + II tumors (p = 0.035). The patients with high-expressed GLUT1 had a worse prognosis than those with low-expressed GLUT1 independently of gender, age, tumor site, stage and differentiation (p = 0.026, RR 2.737, 95% CI 1.126-6.651) in stage I-III CRCs. In liver metastasis, GLUT1 expression was higher in larger tumors than in smaller ones (p = 0.025). Conclusions: Overexpression of GLUT1 in stage I-III CRCs was independently associated with poor prognosis.
Place, publisher, year, edition, pages
Wichtig Editore , 2011. Vol. 26, no 3, 166-172 p.
GLUT1; Colorectal cancer; Prognosis; Real-time PCR
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-73744DOI: 10.5301/JBM.2011.8550ISI: 000297972200004OAI: oai:DiVA.org:liu-73744DiVA: diva2:476374