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Selective IgA Deficiency in Autoimmune Diseases
Karolinska Institute.
Jiao Tong University.
Hammersmith Hospital.
Hammersmith Hospital.
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2011 (English)In: Molecular medicine (Cambridge, Mass. Print), ISSN 1076-1551, E-ISSN 1528-3658, Vol. 17, no 11, 1383-1396 p.Article, review/survey (Refereed) Published
Abstract [en]

Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D). celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) on the basis of both our own recent large-scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the major histocompatibility complex (MHC) region has been reported. In addition, non-MHC genes, such as interferon-induced helicase 1 (IFH1) and c-type lectin domain family 16, member A (CLEC16A), are also associated with the development of IgAD and some of the above diseases. This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders.

Place, publisher, year, edition, pages
Feinstein Institute for Medical Research , 2011. Vol. 17, no 11, 1383-1396 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-73739DOI: 10.2119/molmed.2011.00195ISI: 000297958800029OAI: diva2:476388
Available from: 2012-01-12 Created: 2012-01-12 Last updated: 2014-10-16

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Dahle, Charlotte
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Clinical ImmunologyFaculty of Health SciencesDepartment of Clinical Immunology and Transfusion Medicine
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