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Virus-triggered autophagy in viral hepatitis - possible novel strategies for drug development
Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Tehran.
University of Manitoba.
University of Manitoba.
University of Manitoba.
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2011 (English)In: Journal of Viral Hepatitis, ISSN 1352-0504, E-ISSN 1365-2893, Vol. 18, no 12, 821-830 p.Article, review/survey (Refereed) Published
Abstract [en]

. Autophagy is a very tightly regulated process that is important in many cellular processes including development, differentiation, survival and homoeostasis. The importance of this process has already been proven in numerous common diseases such as cancer and neurodegenerative disorders. Emerging data indicate that autophagy plays an important role in some liver diseases including liver injury induced by ischaemia reperfusion and alpha-1 antitrypsin Z allele-dependent liver disease. Autophagy may also occur in viral infection, and it may play a crucial role in antimicrobial host defence against pathogens, while supporting cellular homoeostasis processes. Here, the latest findings on the role of autophagy in viral hepatitis B and C infection, which are both serious health threats, will be reviewed.

Place, publisher, year, edition, pages
Blackwell Publishing , 2011. Vol. 18, no 12, 821-830 p.
Keyword [en]
autophagy; hepatitis B virus; hepatitis C virus; therapeutic application; virus replication
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-73733DOI: 10.1111/j.1365-2893.2011.01530.xISI: 000297990200001OAI: diva2:476405
Available from: 2012-01-12 Created: 2012-01-12 Last updated: 2014-01-16Bibliographically approved

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Davoodpour, PadidehLos, Marek Jan
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